End stage renal disease-induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived-matrix vesicles.

Cui, Lin; Rashdan, Nabil A; Zhu, Dongxing; Milne, Elspeth M; Ajuh, Paul; Milne, Gillian; Helfrich, Miep H; Lim, Kelvin; Prasad, Sai; Lerman, Daniel A; Vesey, Alex T; Dweck, Marc R; Jenkins, William S; Newby, David E; Farquharson, Colin; Macrae, Vicky E

Cui, Lin; Rashdan, Nabil A; Zhu, Dongxing; Milne, Elspeth M; Ajuh, Paul; Milne, Gillian; Helfrich, Miep H; Lim, Kelvin; Prasad, Sai; Lerman, Daniel A; Vesey, Alex T; Dweck, Marc R; Jenkins, William S; Newby, David E; Farquharson, Colin; Macrae, Vicky E.

Afiliação

Cui L; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh, United Kingdom.
Rashdan NA; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh, United Kingdom.
Zhu D; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh, United Kingdom.
Milne EM; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh, United Kingdom.
Ajuh P; Gemini Biosciences Ltd, Liverpool Science Park, Liverpool, United Kingdom.
Milne G; Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Helfrich MH; Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Lim K; Department of Cardiothoracic Surgery, Royal Infirmary Hospital of Edinburgh (NHS Lothian), The University of Edinburgh, Edinburgh, United Kingdom.
Prasad S; Department of Cardiothoracic Surgery, Royal Infirmary Hospital of Edinburgh (NHS Lothian), The University of Edinburgh, Edinburgh, United Kingdom.
Lerman DA; Department of Cardiothoracic Surgery, Royal Infirmary Hospital of Edinburgh (NHS Lothian), The University of Edinburgh, Edinburgh, United Kingdom.
Vesey AT; University/BHF Center for Cardiovascular Sciences, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom.
Dweck MR; University/BHF Center for Cardiovascular Sciences, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom.
Jenkins WS; University/BHF Center for Cardiovascular Sciences, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom.
Newby DE; University/BHF Center for Cardiovascular Sciences, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom.
Farquharson C; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh, United Kingdom.
Macrae VE; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh, United Kingdom.

J Cell Physiol ; 232(11): 2985-2995, 2017 Nov.

Article em En | MEDLINE | ID: mdl-28369848

Assuntos

Anexina A6/metabolismo; Estenose da Valva Aórtica/metabolismo; Valva Aórtica/metabolismo; Valva Aórtica/patologia; Calcinose/metabolismo; Matriz Extracelular/metabolismo; Vesículas Extracelulares/metabolismo; Hipercalcemia/etiologia; Falência Renal Crônica/complicações; Idoso; Fosfatase Alcalina/genética; Fosfatase Alcalina/metabolismo; Animais; Valva Aórtica/ultraestrutura; Estenose da Valva Aórtica/etiologia; Estenose da Valva Aórtica/genética; Estenose da Valva Aórtica/patologia; Calcinose/etiologia; Calcinose/genética; Calcinose/patologia; Cálcio/metabolismo; Células Cultivadas; Subunidade alfa 1 de Fator de Ligação ao Core/genética; Subunidade alfa 1 de Fator de Ligação ao Core/metabolismo; Matriz Extracelular/ultraestrutura; Vesículas Extracelulares/ultraestrutura; Feminino; Proteínas de Homeodomínio/genética; Proteínas de Homeodomínio/metabolismo; Humanos; Hipercalcemia/diagnóstico; Falência Renal Crônica/diagnóstico; Masculino; Microscopia Eletrônica de Transmissão; Mapas de Interação de Proteínas; Proteômica/métodos; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Ratos Sprague-Dawley; Regulação para Cima

Palavras-chave

Annexin VI; calcific aortic valve disease; calcification; matrix vesicles

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Valva Aórtica / Estenose da Valva Aórtica / Calcinose / Anexina A6 / Matriz Extracelular / Vesículas Extracelulares / Hipercalcemia / Falência Renal Crônica Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies Idioma: En Revista: J Cell Physiol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido

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