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Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD).
Ritter, McKenzie L; Guo, Wei; Samuels, Jack F; Wang, Ying; Nestadt, Paul S; Krasnow, Janice; Greenberg, Benjamin D; Fyer, Abby J; McCracken, James T; Geller, Daniel A; Murphy, Dennis L; Knowles, James A; Grados, Marco A; Riddle, Mark A; Rasmussen, Steven A; McLaughlin, Nicole C; Nurmi, Erika L; Askland, Kathleen D; Cullen, Bernadette; Piacentini, John; Pauls, David L; Bienvenu, Joseph; Stewart, Evelyn; Goes, Fernando S; Maher, Brion; Pulver, Ann E; Mattheisen, Manuel; Qian, Ji; Nestadt, Gerald; Shugart, Yin Yao.
Afiliação
  • Ritter ML; Unit on Statistical Genomics, National Institute of Mental Health, National Institutes of Health (NIH) Bethesda, MD, USA.
  • Guo W; Unit on Statistical Genomics, National Institute of Mental Health, National Institutes of Health (NIH) Bethesda, MD, USA.
  • Samuels JF; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine Baltimore, MD, USA.
  • Wang Y; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine Baltimore, MD, USA.
  • Nestadt PS; Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health Baltimore, MD, USA.
  • Krasnow J; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine Baltimore, MD, USA.
  • Greenberg BD; Department of Psychiatry, Faculty of Medicine, University of Toronto Toronto, ON, Canada.
  • Fyer AJ; New York State Psychiatric Institute, College of Physicians and Surgeons at Columbia University New York, NY, USA.
  • McCracken JT; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine Los Angeles, CA, USA.
  • Geller DA; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School Boston, MA, USA.
  • Murphy DL; Laboratory of Clinical Science, National Institute of Mental Health Bethesda, MD, USA.
  • Knowles JA; Department of Psychiatry and Behavioral Sciences, Keck School of Medicine at the University of Southern California Los Angeles, CA, USA.
  • Grados MA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine Baltimore, MD, USA.
  • Riddle MA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine Baltimore, MD, USA.
  • Rasmussen SA; Department of Psychiatry, Faculty of Medicine, University of Toronto Toronto, ON, Canada.
  • McLaughlin NC; Department of Psychiatry, Faculty of Medicine, University of Toronto Toronto, ON, Canada.
  • Nurmi EL; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine Los Angeles, CA, USA.
  • Askland KD; Department of Psychiatry, Faculty of Medicine, University of Toronto Toronto, ON, Canada.
  • Cullen B; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine Baltimore, MD, USA.
  • Piacentini J; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine Los Angeles, CA, USA.
  • Pauls DL; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School Boston, MA, USA.
  • Bienvenu J; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine Baltimore, MD, USA.
  • Stewart E; Department of Psychiatry, University of British Columbia Vancouver, BC, Canada.
  • Goes FS; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine Baltimore, MD, USA.
  • Maher B; Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health Baltimore, MD, USA.
  • Pulver AE; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine Baltimore, MD, USA.
  • Mattheisen M; Department of Biomedicine and Center for Integrated Sequencing (iSEQ), Aarhus UniversityAarhus, Denmark; Department of Biostatistics, Harvard School of Public HealthBoston, MA, USA; Department of Genomic Mathematics, University of BonnBonn, Germany.
  • Qian J; State Key Laboratory of Genetic Engineering, Life Science Institutes, Fudan University Shanghai, China.
  • Nestadt G; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine Baltimore, MD, USA.
  • Shugart YY; Unit on Statistical Genomics, National Institute of Mental Health, National Institutes of Health (NIH) Bethesda, MD, USA.
Front Mol Neurosci ; 10: 83, 2017.
Article em En | MEDLINE | ID: mdl-28386217
ABSTRACT

Objective:

The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we report the overlap found between these two disorders.

Methods:

A meta-analysis was conducted between ADHD and OCD, and polygenic risk scores (PRS) were calculated for both disorders. In addition, a protein-protein analysis was completed in order to examine the interactions between proteins; p-values for the protein-protein interaction analysis was calculated using permutation.

Conclusion:

None of the single nucleotide polymorphisms (SNPs) reached genome wide significance and there was little evidence of genetic overlap between ADHD and OCD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Mol Neurosci Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Mol Neurosci Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos