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Four Aromatic Sulfates with an Inhibitory Effect against HCV NS3 Helicase from the Crinoid Alloeocomatella polycladia.
Hermawan, Idam; Furuta, Atsushi; Higashi, Masahiro; Fujita, Yoshihisa; Akimitsu, Nobuyoshi; Yamashita, Atsuya; Moriishi, Kohji; Tsuneda, Satoshi; Tani, Hidenori; Nakakoshi, Masamichi; Tsubuki, Masayoshi; Sekiguchi, Yuji; Noda, Naohiro; Tanaka, Junichi.
Afiliação
  • Hermawan I; Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan. hermawan_idam@yahoo.com.
  • Furuta A; Department of Life Science and Medical Bioscience, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan. atsushi.5961@ruri.waseda.jp.
  • Higashi M; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan. atsushi.5961@ruri.waseda.jp.
  • Fujita Y; Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan. higashi@sci.u-ryukyu.ac.jp.
  • Akimitsu N; General Education Center, Okinawa Prefectural University of Arts, 1-4 Shuri Tounokura, Naha, Okinawa 903-8602, Japan. fujitayo@okigei.ac.jp.
  • Yamashita A; Radioisotope Center, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. akimitsu@ric.u-tokyo.ac.jp.
  • Moriishi K; Department of Microbiology, Faculty of Medicine, Graduate School of Interdisciplinary Research, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan. atsuyay@yamanashi.ac.jp.
  • Tsuneda S; Department of Microbiology, Faculty of Medicine, Graduate School of Interdisciplinary Research, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan. kmoriishi@yamanashi.ac.jp.
  • Tani H; Department of Life Science and Medical Bioscience, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan. stsuneda@waseda.jp.
  • Nakakoshi M; Environmental Measurement Research Institute, National Institute of Advanced Industrial Science and Technology, 16-1 Onogawa, Tsukuba, Ibaraki 305-8569, Japan. h.tani@aist.go.jp.
  • Tsubuki M; Department of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi-shi, Chiba 274-8510, Japan. captain.resonance@gmail.com.
  • Sekiguchi Y; Institute of Medical Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. tsubuki@hoshi.ac.jp.
  • Noda N; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan. y.sekiguchi@aist.go.jp.
  • Tanaka J; Department of Life Science and Medical Bioscience, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan. noda-naohiro@aist.go.jp.
Mar Drugs ; 15(4)2017 Apr 11.
Article em En | MEDLINE | ID: mdl-28398249
ABSTRACT
Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules cholesterol sulfate and four new aromatic sulfates 1-4. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates 1-4 showed moderate inhibition against NS3 helicase with IC50 values of 71, 95, 7, and 5 µM, respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Sulfatos / Proteínas não Estruturais Virais / RNA Helicases / Equinodermos / Organismos Aquáticos Limite: Animals Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Sulfatos / Proteínas não Estruturais Virais / RNA Helicases / Equinodermos / Organismos Aquáticos Limite: Animals Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão