Vectorization of ultrasound-responsive nanoparticles in placental mesenchymal stem cells for cancer therapy.
Nanoscale
; 9(17): 5528-5537, 2017 May 04.
Article
em En
| MEDLINE
| ID: mdl-28402365
ABSTRACT
A new platform constituted by engineered responsive nanoparticles transported by human mesenchymal stem cells is here presented as a proof of concept. Ultrasound-responsive mesoporous silica nanoparticles are coated with polyethylenimine to favor their effective uptake by decidua-derived mesenchymal stem cells. The responsive-release ability of the designed nanoparticles is confirmed, both in vial and in vivo. In addition, this capability is maintained inside the cells used as carriers. The migration capacity of the nanoparticle-cell platform towards mammary tumors is assessed in vitro. The efficacy of this platform for anticancer therapy is shown against mammary tumor cells by inducing the release of doxorubicin only when the cell vehicles are exposed to ultrasound.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
/
Decídua
/
Nanopartículas
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Células-Tronco Mesenquimais
/
Neoplasias Mamárias Experimentais
Limite:
Animals
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Female
/
Humans
Idioma:
En
Revista:
Nanoscale
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Espanha