Origin and Function of the Renal Stroma in Health and Disease.
Results Probl Cell Differ
; 60: 205-229, 2017.
Article
em En
| MEDLINE
| ID: mdl-28409347
ABSTRACT
The renal stroma is defined as a heterogeneous population of cells that serve both as a supportive framework and as a source of specialized cells in the renal capsule, glomerulus, vasculature, and interstitium. In this chapter, we review published evidence defining what, where, and why stromal cells are important. We describe the functions of the renal stroma andhow stromal derivatives are crucial for normal kidney function. Next, we review the specification of stromal cells from the Osr1+ intermediate mesoderm and T+ presomitic mesoderm during embryogenesis and stromal cell differentiation. We focus on stromal signaling mechanisms that act in both a cell and non-cell autonomous manner in communication with the nephron progenitor and ureteric lineages. To conclude, stromal cells and the contribution of stromal cells to renal fibrosis and chronic kidney disease are described.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Estromais
/
Organogênese
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Matriz Extracelular
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Rim
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Results Probl Cell Differ
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Canadá