Sex differences in the association of cutaneous melanoma incidence rates and geographic ultraviolet light exposure.
J Am Acad Dermatol
; 76(3): 499-505.e3, 2017 Mar.
Article
em En
| MEDLINE
| ID: mdl-28413057
ABSTRACT
BACKGROUND:
Cutaneous melanoma (CM) incidence rates continue to increase, and the reasons are unknown. Previously, we reported a unique age-specific sex difference in melanoma that suggested additional causes other than solar ultraviolet (UV) radiation.OBJECTIVE:
This study attempted to understand whether and how UV radiation differentially impacts the CM incidence in men and women.METHODS:
CM data and daily UV index (UVI) from 31 cancer registries were collected for association analysis. A second dataset from 42 US states was used for validation.RESULTS:
There was no association between log-transformed female CM rates and levels of UVI, but there was a significant association between male rates and UVI and a significant association between overall rates and UVI. The 5-year age-specific rate-UVI association levels (represented by Pearson's coefficient ρ) increased with age in men, but age-specific ρ levels remained low and unchanged in women. The significant rate-UVI association in men and nonassociation in women was validated in a population of white residents of the United States.LIMITATIONS:
Confounders, including temperature and latitude, are difficult to separate from UVI.CONCLUSIONS:
Ambient UVI appears to be associated with melanoma incidence in males but not in females.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Raios Ultravioleta
/
Exposição Ambiental
/
Melanoma
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
America do norte
/
Europa
/
Oceania
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
2017
Tipo de documento:
Article