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Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.
Sanders, John M; Beshore, Douglas C; Culberson, J Christopher; Fells, James I; Imbriglio, Jason E; Gunaydin, Hakan; Haidle, Andrew M; Labroli, Marc; Mattioni, Brian E; Sciammetta, Nunzio; Shipe, William D; Sheridan, Robert P; Suen, Linda M; Verras, Andreas; Walji, Abbas; Joshi, Elizabeth M; Bueters, Tjerk.
Afiliação
  • Sanders JM; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Beshore DC; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Culberson JC; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Fells JI; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Imbriglio JE; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Gunaydin H; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Haidle AM; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Labroli M; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Mattioni BE; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Sciammetta N; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Shipe WD; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Sheridan RP; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Suen LM; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Verras A; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Walji A; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Joshi EM; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
  • Bueters T; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States.
J Med Chem ; 60(16): 6771-6780, 2017 08 24.
Article em En | MEDLINE | ID: mdl-28418656
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Descoberta de Drogas / Ensaios de Triagem em Larga Escala Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Descoberta de Drogas / Ensaios de Triagem em Larga Escala Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos