Cervical Strip Biopsy for High-Grade Cervical Intraepithelial Lesions: a Valid Alternative to Conventional Punch Technique.
Geburtshilfe Frauenheilkd
; 75(10): 1063-1068, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-28435170
ABSTRACT
Introduction:
To evaluate, if targeted strip biopsies decrease trauma/pain perception while maintaining diagnostic accuracy in patients with the diagnosis of high-grade squamous intraepithelial lesions of the uterine cervix. Patients andMethods:
Between July 1st and December 31st 2014 we performed colposcopically directed strip biopsies in 102 patients with colposcopic suspicion of high-grade squamous intraepithelial lesions of the uterine cervix. We used a 3 mm curette for harvesting tissue samples under VITOM® videocolposcopy. So far, 60 patients underwent additional loop excision. Histologic examination of strip biopsies and loop specimens included routine hematoxylin and eosin staining as well as immunohistochemical staining for p16, Ki 67 and stathmin-1.Results:
55 patients (53â%), were histologically diagnosed with cervical intraepithelial neoplasia grade 3 on strip biopsies. Adenocarcinoma in situ was diagnosed in 2 patients (2â%), cervical intraepithelial neoplasia grade 2 in 35 patients (34â%), and cervical intraepithelial neoplasia grade 1 in 10 patients (10â%). The agreement between histologic results of strip biopsy and loop specimen was highly significant In all 60 strip biopsies diagnosed with high-grade squamous intraepithelial lesions this diagnosis was confirmed histologically during follow-up loop specimen excision (high-grade squamous intraepithelial lesions in 58 patients, invasive disease in 2 patients). The pain level experienced during strip biopsy was rated on average 0.25 on a scale from 0 to 10. No clinically significant bleeding was reported.Conclusion:
Targeted strip biopsies with a 3 mm curette are a reliable procedure to diagnose high-grade squamous intraepithelial lesions of the uterine cervix and yield high patient satisfaction (Video 1).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Geburtshilfe Frauenheilkd
Ano de publicação:
2015
Tipo de documento:
Article