Features of Dengue and Chikungunya Infections of Colombian Children under 24 Months of Age Admitted to the Emergency Department.
J Trop Pediatr
; 64(1): 31-37, 2018 02 01.
Article
em En
| MEDLINE
| ID: mdl-28444295
ABSTRACT
We aimed to assess clinical and laboratory differences between dengue and chikungunya in children <24 months of age in a comparative study. We collected retrospective clinical and laboratory data confirmed by NS1/IgM for dengue for 19 months (1 January 2013 to 17 August 2014). Prospective data for chikungunya confirmed by real-time polymerase chain reaction were collected for 4 months (22 September 2014-14 December 2014). Sensitivity and specificity [with 95% confidence interval (CI)] were reported for each disease diagnosis. A platelet count <150 000 cells/ml at emergency admission best characterized dengue, with a sensitivity of 67% (95% CI, 53-79) and specificity of 95% (95% CI, 82-99). The algorithm developed with classification and regression tree analysis showed a sensitivity of 93% (95% CI, 68-100) and specificity of 38% (95% CI, 9-76) to diagnose dengue. Our study provides potential differential characteristics between chikungunya and dengue in young children, especially low platelet counts.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dengue
/
Febre de Chikungunya
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Humans
/
Infant
/
Newborn
País/Região como assunto:
America do sul
/
Colombia
Idioma:
En
Revista:
J Trop Pediatr
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Colômbia