A dosing algorithm for metformin based on the relationships between exposure and renal clearance of metformin in patients with varying degrees of kidney function.

Duong, Janna K; Kroonen, M Y A M; Kumar, S S; Heerspink, H L; Kirkpatrick, C M; Graham, G G; Williams, K M; Day, R O

Duong, Janna K; Kroonen, M Y A M; Kumar, S S; Heerspink, H L; Kirkpatrick, C M; Graham, G G; Williams, K M; Day, R O.

Afiliação

Duong JK; School of Medical Sciences, Medicine, University of New South Wales, Sydney, Australia. jkduong@gmail.com.
Kroonen MYAM; Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Sydney, Australia. jkduong@gmail.com.
Kumar SS; Faculty of Pharmacy, The University of Sydney, Sydney, NSW, 2006, Australia. jkduong@gmail.com.
Heerspink HL; Department of Pharmacy and Pharmacology, University of Groningen, Groningen, The Netherlands.
Kirkpatrick CM; School of Medical Sciences, Medicine, University of New South Wales, Sydney, Australia.
Graham GG; Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Sydney, Australia.
Williams KM; Department of Pharmacy and Pharmacology, University of Groningen, Groningen, The Netherlands.
Day RO; Centre for Medicine Use and Safety, Monash University, Parkville, Australia.

Eur J Clin Pharmacol ; 73(8): 981-990, 2017 Aug.

Article em En | MEDLINE | ID: mdl-28451709

Assuntos

Hipoglicemiantes/administração & dosagem; Hipoglicemiantes/farmacocinética; Rim/metabolismo; Metformina/administração & dosagem; Metformina/farmacocinética; Modelos Biológicos; Adulto; Idoso; Idoso de 80 Anos ou mais; Algoritmos; Diabetes Mellitus Tipo 2/tratamento farmacológico; Diabetes Mellitus Tipo 2/metabolismo; Diabetes Mellitus Tipo 2/fisiopatologia; Relação Dose-Resposta a Droga; Feminino; Humanos; Hipoglicemiantes/sangue; Hipoglicemiantes/urina; Rim/fisiopatologia; Nefropatias/tratamento farmacológico; Nefropatias/metabolismo; Nefropatias/fisiopatologia; Masculino; Metformina/sangue; Metformina/urina; Pessoa de Meia-Idade

Palavras-chave

Kidney disease; Metformin; Pharmacokinetics; Population modelling; Renal clearance; Type 2 diabetes mellitus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipoglicemiantes / Rim / Metformina / Modelos Biológicos Tipo de estudo: Guideline / Observational_studies / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Clin Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Austrália

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