Tailoring Medulloblastoma Treatment Through Genomics: Making a Change, One Subgroup at a Time.
Annu Rev Genomics Hum Genet
; 18: 143-166, 2017 08 31.
Article
em En
| MEDLINE
| ID: mdl-28475368
ABSTRACT
After more than a decade of genomic studies in medulloblastoma, the time has come to capitalize on the knowledge gained and use it to directly improve patient care. Although metastatic and relapsed disease remain poorly understood, much has changed in how we define medulloblastoma, and it has become evident that with conventional therapies, specific groups of patients are currently under- or overtreated. In this review, we summarize the latest insights into medulloblastoma biology, focusing on how genomics is affecting patient stratification, informing preclinical studies of targeted therapies, and shaping the new generation of clinical trials.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cerebelares
/
Genômica
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Terapia de Alvo Molecular
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Meduloblastoma
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Genomics Hum Genet
Assunto da revista:
GENETICA
/
GENETICA MEDICA
Ano de publicação:
2017
Tipo de documento:
Article