Endocytic receptor LRP2/megalin-of holoprosencephaly and renal Fanconi syndrome.
Pflugers Arch
; 469(7-8): 907-916, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28497274
ABSTRACT
Megalin (or LRP2) is an endocytic receptor that plays a central role in embryonic development and adult tissue homeostasis. Loss of this receptor in congenital or acquired diseases results in multiple organ dysfunctions, including forebrain malformation (holoprosencephaly) and renal reabsorption defects (renal Fanconi syndrome). Here, we describe current concepts of the mode of receptor action that include co-receptors and a repertoire of different ligands, and we discuss how these interactions govern functional integrity of the kidney and the brain, and cause disease when defective.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Holoprosencefalia
/
Proteína-2 Relacionada a Receptor de Lipoproteína de Baixa Densidade
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Síndrome de Fanconi
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Pflugers Arch
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Alemanha