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Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies.
Goel, Gautam; King, Tim; Daveson, A James; Andrews, Jane M; Krishnarajah, Janakan; Krause, Richard; Brown, Gregor J E; Fogel, Ronald; Barish, Charles F; Epstein, Roger; Kinney, Timothy P; Miner, Philip B; Tye-Din, Jason A; Girardin, Adam; Taavela, Juha; Popp, Alina; Sidney, John; Mäki, Markku; Goldstein, Kaela E; Griffin, Patrick H; Wang, Suyue; Dzuris, John L; Williams, Leslie J; Sette, Alessandro; Xavier, Ramnik J; Sollid, Ludvig M; Jabri, Bana; Anderson, Robert P.
Afiliação
  • Goel G; Division of Gastroenterology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.
  • King T; Department of Gastroenterology, Auckland City Hospital, Auckland, New Zealand.
  • Daveson AJ; School of Medicine, University of Queensland, Brisbane, QLD, Australia.
  • Andrews JM; Department of Gastroenterology & Hepatology, Royal Adelaide Hospital, Adelaide, SA, Australia.
  • Krishnarajah J; Linear Clinical Research, Nedlands, WA, Australia.
  • Krause R; ClinSearch, Chattanooga, TN, USA.
  • Brown GJE; Department of Gastroenterology, Alfred Hospital, Prahran, VIC, Australia.
  • Fogel R; Clinical Research Institute of Michigan, Chesterfield, MI, USA.
  • Barish CF; University of North Carolina School of Medicine, Chapel Hill, NC, USA; Wake Gastroenterology and Wake Research Associates, Raleigh, NC, USA.
  • Epstein R; Atlantic Digestive Specialists, Portsmouth, NH, USA.
  • Kinney TP; Ridgeview Medical Center, Waconia, MN, USA.
  • Miner PB; Oklahoma Foundation for Digestive Research, Oklahoma City, OK, USA.
  • Tye-Din JA; Immunology Division, Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia; Murdoch Children's Research Institute and Department of Gastroenterology, Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Girardin A; Immunology Division, Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
  • Taavela J; Tampere Center for Child Health Research and Department of Pediatrics, University of Tampere Faculty of Medicine and Life Sciences and Tampere University Hospital, Tampere, Finland.
  • Popp A; Tampere Center for Child Health Research and Department of Pediatrics, University of Tampere Faculty of Medicine and Life Sciences and Tampere University Hospital, Tampere, Finland; Alfred Rusescu Institute for Mother and Child Care and Carol Davila University of Medicine and Pharmacy, Bucharest, Ro
  • Sidney J; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.
  • Mäki M; Tampere Center for Child Health Research and Department of Pediatrics, University of Tampere Faculty of Medicine and Life Sciences and Tampere University Hospital, Tampere, Finland.
  • Goldstein KE; ImmusanT, Cambridge, MA, USA.
  • Griffin PH; ImmusanT, Cambridge, MA, USA.
  • Wang S; ImmusanT, Cambridge, MA, USA.
  • Dzuris JL; ImmusanT, Cambridge, MA, USA.
  • Williams LJ; ImmusanT, Cambridge, MA, USA.
  • Sette A; Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.
  • Xavier RJ; Division of Gastroenterology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Sollid LM; Centre for Immune Regulation, KG Jebsen Coeliac Disease Research Centre, and Department of Immunology, University of Oslo, Oslo, Norway; Oslo University Hospital-Rikshospitalet, Oslo, Norway.
  • Jabri B; Department of Pediatrics, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Anderson RP; ImmusanT, Cambridge, MA, USA. Electronic address: bob@immusant.com.
Lancet Gastroenterol Hepatol ; 2(7): 479-493, 2017 07.
Article em En | MEDLINE | ID: mdl-28506538
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Vacinas / Linfócitos T CD4-Positivos / Doença Celíaca / Epitopos Tipo de estudo: Clinical_trials / Etiology_studies / Guideline Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Oceania Idioma: En Revista: Lancet Gastroenterol Hepatol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Vacinas / Linfócitos T CD4-Positivos / Doença Celíaca / Epitopos Tipo de estudo: Clinical_trials / Etiology_studies / Guideline Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Oceania Idioma: En Revista: Lancet Gastroenterol Hepatol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos