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The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/ß-catenin pathway by inhibiting the proteasome.
Yi, Jason J; Paranjape, Smita R; Walker, Matthew P; Choudhury, Rajarshi; Wolter, Justin M; Fragola, Giulia; Emanuele, Michael J; Major, Michael B; Zylka, Mark J.
Afiliação
  • Yi JJ; Department of Neuroscience, Washington University School of Medicine, Saint Louis, Missouri 63110.
  • Paranjape SR; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599; UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Walker MP; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Choudhury R; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Wolter JM; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599; UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Fragola G; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599; UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Emanuele MJ; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Major MB; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Zylka MJ; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599; UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599; Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, North Ca
J Biol Chem ; 292(30): 12503-12515, 2017 07 28.
Article em En | MEDLINE | ID: mdl-28559284
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Autístico / Ubiquitina-Proteína Ligases / Complexo de Endopeptidases do Proteassoma / Beta Catenina / Via de Sinalização Wnt / Inibidores de Proteassoma / Mutação Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Autístico / Ubiquitina-Proteína Ligases / Complexo de Endopeptidases do Proteassoma / Beta Catenina / Via de Sinalização Wnt / Inibidores de Proteassoma / Mutação Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article