Pd(0)-Catalyzed intramolecular arylative dearomatization of ß-naphthols.

ABSTRACT

An efficient Pd(0)-catalyzed intramolecular arylative dearomatization of ß-naphthols is described. Using Q-Phos as a ligand, the arylative dearomatization reaction proceeded smoothly affording excellent yields and chemoselectivity even when the catalyst loading was reduced to 0.1 mol%. This method offers an efficient access to a series of structurally diverse spirocarbocycles. Preliminary investigation indicates that an enantioselective reaction is feasible in the presence of a chiral phosphoramidite ligand.