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Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis.
Deyou, Tsegaye; Marco, Makungu; Heydenreich, Matthias; Pan, Fangfang; Gruhonjic, Amra; Fitzpatrick, Paul A; Koch, Andreas; Derese, Solomon; Pelletier, Jerry; Rissanen, Kari; Yenesew, Abiy; Erdélyi, Máté.
Afiliação
  • Deyou T; Department of Chemistry, University of Nairobi , P.O. Box 30197-00100, Nairobi, Kenya.
  • Marco M; Department of Chemistry and Molecular Biology, University of Gothenburg , SE-412 96 Gothenburg, Sweden.
  • Heydenreich M; Department of Chemistry, University of Nairobi , P.O. Box 30197-00100, Nairobi, Kenya.
  • Pan F; Institut für Chemie, Universität Potsdam , Karl-Liebknecht-Straße 24-25, D-14476, Potsdam, Germany.
  • Gruhonjic A; Department of Chemistry, Nanoscience Center, University of Jyvaskyla , P.O. Box 35, FI-40014, Jyvaskyla, Finland.
  • Fitzpatrick PA; College of Chemistry, Central China Normal University , Wuhan, 430079, People's Republic of China.
  • Koch A; Department of Chemistry and Molecular Biology, University of Gothenburg , SE-412 96 Gothenburg, Sweden.
  • Derese S; Sahlgrenska Cancer Centre, University of Gothenburg , SE-405 30 Gothenburg, Sweden.
  • Pelletier J; Sahlgrenska Cancer Centre, University of Gothenburg , SE-405 30 Gothenburg, Sweden.
  • Rissanen K; Institut für Chemie, Universität Potsdam , Karl-Liebknecht-Straße 24-25, D-14476, Potsdam, Germany.
  • Yenesew A; Department of Chemistry, University of Nairobi , P.O. Box 30197-00100, Nairobi, Kenya.
  • Erdélyi M; Department of Biochemistry, McGill University , Montreal, QC H3G 1Y6, Canada.
J Nat Prod ; 80(7): 2060-2066, 2017 07 28.
Article em En | MEDLINE | ID: mdl-28665590
ABSTRACT
A new isoflavone, 8-prenylmilldrone (1), and four new rotenoids, oblarotenoids A-D (2-5), along with nine known compounds (6-14), were isolated from the CH2Cl2/CH3OH (11) extract of the leaves of Millettia oblata ssp. teitensis by chromatographic separation. The purified compounds were identified by NMR spectroscopic and mass spectrometric analyses, whereas the absolute configurations of the rotenoids were established on the basis of chiroptical data and in some cases by single-crystal X-ray crystallography. Maximaisoflavone J (11) and oblarotenoid C (4) showed weak activity against the human breast cancer cell line MDA-MB-231 with IC50 values of 33.3 and 93.8 µM, respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rotenona / Folhas de Planta / Millettia / Isoflavonas Limite: Humans País/Região como assunto: Africa Idioma: En Revista: J Nat Prod Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Quênia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rotenona / Folhas de Planta / Millettia / Isoflavonas Limite: Humans País/Região como assunto: Africa Idioma: En Revista: J Nat Prod Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Quênia