Plasmids of Diverse Inc Groups Disseminate the Fosfomycin Resistance Gene <i>fosA3</i> among Escherichia coli Isolates from Pigs, Chickens, and Dairy Cows in Northeast China.

Wang, Xiu-Mei; Dong, Zhimin; Schwarz, Stefan; Zhu, Yao; Hua, Xin; Zhang, Yanhe; Liu, Siguo; Zhang, Wan-Jiang

Plasmids of Diverse Inc Groups Disseminate the Fosfomycin Resistance Gene fosA3 among Escherichia coli Isolates from Pigs, Chickens, and Dairy Cows in Northeast China.

Wang, Xiu-Mei; Dong, Zhimin; Schwarz, Stefan; Zhu, Yao; Hua, Xin; Zhang, Yanhe; Liu, Siguo; Zhang, Wan-Jiang.

Afiliação

Wang XM; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Dong Z; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Schwarz S; Institute of Microbiology and Epizootics, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
Zhu Y; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Hua X; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Zhang Y; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Liu S; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China siguo_liu@hvri.ac.cn wjzhang@hvri.ac.cn.
Zhang WJ; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China siguo_liu@hvri.ac.cn wjzhang@hvri.ac.cn.

Antimicrob Agents Chemother ; 61(9)2017 09.

Article em En | MEDLINE | ID: mdl-28674050

ABSTRACT

ABSTRACT

Thirty-nine fosfomycin-resistant Escherichia coli isolates carrying fosA3 were obtained from pigs, chickens, dairy cows, and staff in four northeastern provinces of China between June 2015 and April 2016. The fosA3 gene was colocated with blaCTX-M genes on conjugative plasmids of the incompatibility groups IncN (n = 12), IncN-F33A-B-(n = 2), IncF33A-B-(n = 14), IncF14A-B-(n = 2), and IncI1/sequence type 136 (ST136) (n = 9). Four different genetic contexts of fosA3 were detected among the 39 E. coli isolates. Three potential epidemic plasmids circulated among E. coli strains from this region.

Assuntos

Farmacorresistência Bacteriana/genética; Proteínas de Escherichia coli/genética; Escherichia coli/efeitos dos fármacos; Escherichia coli/genética; Fosfomicina/farmacologia; Plasmídeos/genética; Animais; Bovinos; Galinhas/microbiologia; China; Infecções por Escherichia coli/microbiologia; Testes de Sensibilidade Microbiana/métodos; Suínos/microbiologia

Palavras-chave

CTX-M; antibiotic resistance; horizontal dissemination; resistance genes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmídeos / Proteínas de Escherichia coli / Farmacorresistência Bacteriana / Escherichia coli / Fosfomicina Limite: Animals País/Região como assunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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