Spatial distribution of EGFR and KRAS mutation frequencies correlates with histological growth patterns of lung adenocarcinomas.

Dietz, Steffen; Harms, Alexander; Endris, Volker; Eichhorn, Florian; Kriegsmann, Mark; Longuespée, Rémi; Stenzinger, Albrecht; Sültmann, Holger; Warth, Arne; Kazdal, Daniel

Dietz, Steffen; Harms, Alexander; Endris, Volker; Eichhorn, Florian; Kriegsmann, Mark; Longuespée, Rémi; Stenzinger, Albrecht; Sültmann, Holger; Warth, Arne; Kazdal, Daniel.

Afiliação

Dietz S; Cancer Genome Research Group, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Harms A; Member of the Translational Lung Research Center (TLRC) Heidelberg, German Center for Lung Research (DZL), Heidelberg, Germany.
Endris V; Member of the German Cancer Consortium (DKTK), Heidelberg, Germany.
Eichhorn F; Member of the Translational Lung Research Center (TLRC) Heidelberg, German Center for Lung Research (DZL), Heidelberg, Germany.
Kriegsmann M; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Longuespée R; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Stenzinger A; Department of Thoracic Surgery, Thoraxklinik at the University Hospital Heidelberg, Heidelberg, Germany.
Sültmann H; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Warth A; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Kazdal D; Member of the German Cancer Consortium (DKTK), Heidelberg, Germany.

Int J Cancer ; 141(9): 1841-1848, 2017 11 01.

Article em En | MEDLINE | ID: mdl-28699162

Assuntos

Adenocarcinoma/genética; Receptores ErbB/genética; Heterogeneidade Genética; Neoplasias Pulmonares/genética; Proteínas Proto-Oncogênicas p21(ras)/genética; Adenocarcinoma/patologia; Adenocarcinoma de Pulmão; Idoso; Idoso de 80 Anos ou mais; Feminino; Frequência do Gene; Humanos; Neoplasias Pulmonares/patologia; Masculino; Pessoa de Meia-Idade; Mutação

Palavras-chave

driver gene mutation allele frequency; heterogeneity; histological growth pattern; lung adenocarcinoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenocarcinoma / Proteínas Proto-Oncogênicas p21(ras) / Heterogeneidade Genética / Receptores ErbB / Neoplasias Pulmonares Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Cancer Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha

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