Your browser doesn't support javascript.
loading
Role of the ß Common (ßc) Family of Cytokines in Health and Disease.
Hercus, Timothy R; Kan, Winnie L T; Broughton, Sophie E; Tvorogov, Denis; Ramshaw, Hayley S; Sandow, Jarrod J; Nero, Tracy L; Dhagat, Urmi; Thompson, Emma J; Shing, Karen S Cheung Tung; McKenzie, Duncan R; Wilson, Nicholas J; Owczarek, Catherine M; Vairo, Gino; Nash, Andrew D; Tergaonkar, Vinay; Hughes, Timothy; Ekert, Paul G; Samuel, Michael S; Bonder, Claudine S; Grimbaldeston, Michele A; Parker, Michael W; Lopez, Angel F.
Afiliação
  • Hercus TR; The Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia 5000, Australia.
  • Kan WLT; The Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia 5000, Australia.
  • Broughton SE; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia.
  • Tvorogov D; The Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia 5000, Australia.
  • Ramshaw HS; The Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia 5000, Australia.
  • Sandow JJ; Division of Systems Biology and Personalised Medicine, The Walter and Eliza Hall Institute; and Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3052, Australia.
  • Nero TL; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia.
  • Dhagat U; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia.
  • Thompson EJ; The Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia 5000, Australia.
  • Shing KSCT; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia.
  • McKenzie DR; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.
  • Wilson NJ; The Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia 5000, Australia.
  • Owczarek CM; CSL Limited, Parkville, Victoria 3010, Australia.
  • Vairo G; CSL Limited, Parkville, Victoria 3010, Australia.
  • Nash AD; CSL Limited, Parkville, Victoria 3010, Australia.
  • Tergaonkar V; CSL Limited, Parkville, Victoria 3010, Australia.
  • Hughes T; The Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia 5000, Australia.
  • Ekert PG; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673, Singapore.
  • Samuel MS; The Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia 5000, Australia.
  • Bonder CS; South Australian Health and Medical Research Institute and University of Adelaide, North Terrace, Adelaide, South Australia 5000, Australia.
  • Grimbaldeston MA; Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia.
  • Parker MW; The Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia 5000, Australia.
  • Lopez AF; School of Medicine, University of Adelaide, Adelaide, South Australia 5000, Australia.
Cold Spring Harb Perspect Biol ; 10(6)2018 06 01.
Article em En | MEDLINE | ID: mdl-28716883
ABSTRACT
The ß common ([ßc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which use ßc as their key signaling receptor subunit. This is a prototypic signaling subunit-sharing cytokine family that has unveiled many biological paradigms and structural principles applicable to the IL-2, IL-4, and IL-6 receptor families, all of which also share one or more signaling subunits. Originally identified for their functions in the hematopoietic system, the ßc cytokines are now known to be truly pleiotropic, impacting on multiple cell types, organs, and biological systems, and thereby controlling the balance between health and disease. This review will focus on the emerging biological roles for the ßc cytokines, our progress toward understanding the mechanisms of receptor assembly and signaling, and the application of this knowledge to develop exciting new therapeutic approaches against human disease.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocinas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cold Spring Harb Perspect Biol Assunto da revista: BIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocinas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cold Spring Harb Perspect Biol Assunto da revista: BIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Austrália