N-acyl dopamines induce apoptosis in PC12 cell line via the GPR55 receptor activation.

Akimov, M G; Ashba, A M; Gretskaya, N M; Bezuglov, V V

Akimov, M G; Ashba, A M; Gretskaya, N M; Bezuglov, V V.

Afiliação

Akimov MG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia. akimovmike@yandex.ru.
Ashba AM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
Gretskaya NM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
Bezuglov VV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.

Dokl Biochem Biophys ; 474(1): 155-158, 2017 May.

Article em En | MEDLINE | ID: mdl-28726104

ABSTRACT

ABSTRACT

Dopamine amides of arachidonic, docosahexaenoic, and oleic acids were found to induce apoptosis in PC12 cells, which was blocked exclusively by antagonists and preincubation agonists of the receptor GPR55, belonging to the group of non-CB1/CB2 receptors.

Assuntos

Apoptose/efeitos dos fármacos; Dopamina/química; Dopamina/farmacologia; Receptores de Canabinoides/metabolismo; Receptores Acoplados a Proteínas G/metabolismo; Animais; Cinética; Células PC12; Ratos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dopamina / Apoptose / Receptores Acoplados a Proteínas G / Receptores de Canabinoides Limite: Animals Idioma: En Revista: Dokl Biochem Biophys Assunto da revista: BIOFISICA / BIOQUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Federação Russa

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