Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF.
Nat Cell Biol
; 19(8): 974-987, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28737771
ABSTRACT
Obesity is associated with chronic, low-grade inflammation, which can disrupt homeostasis within tissue microenvironments. Given the correlation between obesity and relative risk of death from cancer, we investigated whether obesity-associated inflammation promotes metastatic progression. We demonstrate that obesity causes lung neutrophilia in otherwise normal mice, which is further exacerbated by the presence of a primary tumour. The increase in lung neutrophils translates to increased breast cancer metastasis to this site, in a GM-CSF- and IL5-dependent manner. Importantly, weight loss is sufficient to reverse this effect, and reduce serum levels of GM-CSF and IL5 in both mouse models and humans. Our data indicate that special consideration of the obese patient population is critical for effective management of cancer progression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumonia
/
Neoplasias da Mama
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Fator Estimulador de Colônias de Granulócitos e Macrófagos
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Interleucina-5
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Infiltração de Neutrófilos
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Pulmão
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Neoplasias Pulmonares
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Neutrófilos
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Obesidade
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Idioma:
En
Revista:
Nat Cell Biol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos