Peptides Selected Using Phage Library Variants, Effectively Inhibit Trypanosoma cruzi Infection.
Bull Exp Biol Med
; 163(3): 361-364, 2017 Jul.
Article
em En
| MEDLINE
| ID: mdl-28744646
ABSTRACT
Four peptide sequences characterized by high content of hydrophobic, charged, and polar amino acids were obtained from 23 clones of M13 phage. Peptides P2 and P4 exhibited highest binding affinity for immobilized trypomastigotes. The inhibitory effects of peptides seemed to be due to blockade of certain epitopes on T. cruzi surface proteins responsible for interactions with the respective receptors of host cells.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Tripanossomicidas
/
Trypanosoma cruzi
/
Biblioteca de Peptídeos
/
Estágios do Ciclo de Vida
Limite:
Humans
Idioma:
En
Revista:
Bull Exp Biol Med
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Federação Russa