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Peptides Selected Using Phage Library Variants, Effectively Inhibit Trypanosoma cruzi Infection.
Kleshchenko, Yu E; Zhigunova, A V; Dalin, M V; Melnikov, V.
Afiliação
  • Kleshchenko YE; Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia, Moscow, Russia. ykleschenko@gmail.com.
  • Zhigunova AV; Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia, Moscow, Russia.
  • Dalin MV; Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia, Moscow, Russia.
  • Melnikov V; Laboratory of Molecular Biology, School of Medicine, University of Colima, Colima, Mexico.
Bull Exp Biol Med ; 163(3): 361-364, 2017 Jul.
Article em En | MEDLINE | ID: mdl-28744646
ABSTRACT
Four peptide sequences characterized by high content of hydrophobic, charged, and polar amino acids were obtained from 23 clones of M13 phage. Peptides P2 and P4 exhibited highest binding affinity for immobilized trypomastigotes. The inhibitory effects of peptides seemed to be due to blockade of certain epitopes on T. cruzi surface proteins responsible for interactions with the respective receptors of host cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Tripanossomicidas / Trypanosoma cruzi / Biblioteca de Peptídeos / Estágios do Ciclo de Vida Limite: Humans Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Federação Russa
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Tripanossomicidas / Trypanosoma cruzi / Biblioteca de Peptídeos / Estágios do Ciclo de Vida Limite: Humans Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Federação Russa