Your browser doesn't support javascript.
loading
Molecular Characterization of Fluoroquinolone-Resistant Moraxella catarrhalis Variants Generated In Vitro by Stepwise Selection.
Yamada, Kageto; Saito, Ryoichi; Muto, Saori; Kashiwa, Machiko; Tamamori, Yoshiko; Fujisaki, Shingo.
Afiliação
  • Yamada K; Department of Biomolecular Science, Faculty of Science, Toho University, Chiba, Japan kageto_yamada@tokyo-hmt.jp.
  • Saito R; Department of Clinical Laboratory, Tokyo Metropolitan Health and Medical Treatment Corporation Toshima Hospital, Tokyo, Japan.
  • Muto S; Department of Microbiology and Immunology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
  • Kashiwa M; Department of Clinical Laboratory, Tokyo Metropolitan Health and Medical Treatment Corporation Toshima Hospital, Tokyo, Japan.
  • Tamamori Y; Department of Clinical Laboratory, Tokyo Metropolitan Health and Medical Treatment Corporation Toshima Hospital, Tokyo, Japan.
  • Fujisaki S; Department of Clinical Laboratory, Tokyo Metropolitan Health and Medical Treatment Corporation Toshima Hospital, Tokyo, Japan.
Antimicrob Agents Chemother ; 61(10)2017 10.
Article em En | MEDLINE | ID: mdl-28760904
ABSTRACT
Moraxella catarrhalis causes respiratory infections. In this study, fluoroquinolone-resistant strains were selected in vitro to evaluate the mechanism of fluoroquinolone resistance. Strains with reduced fluoroquinolone susceptibility were obtained by stepwise selection in levofloxacin, and fluoroquinolone targets gyr and par were sequenced. Six novel mutations in GyrA (D84Y, T594dup, and A722dup), GyrB (E479K and D439N), and ParE (Q395R) involved in M. catarrhalis resistance to fluoroquinolones were revealed.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Moraxella catarrhalis / DNA Girase / DNA Topoisomerase IV / Inibidores da Topoisomerase / Levofloxacino / Antibacterianos Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Moraxella catarrhalis / DNA Girase / DNA Topoisomerase IV / Inibidores da Topoisomerase / Levofloxacino / Antibacterianos Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão