New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia.
Blood
; 130(12): 1395-1401, 2017 09 21.
Article
em En
| MEDLINE
| ID: mdl-28778863
ABSTRACT
Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1-like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for up to 50% of previously unclassified pediatric BCP-ALL cases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia-Linfoma Linfoblástico de Células Precursoras B
Limite:
Child
/
Humans
Idioma:
En
Revista:
Blood
Ano de publicação:
2017
Tipo de documento:
Article