Vitamin D predictors in polycystic ovary syndrome: a meta-analysis.
Eur J Clin Invest
; 47(10): 746-755, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-28795765
ABSTRACT
BACKGROUND:
The aim of this meta-analysis was to examine differences and predictors of serum 25-hydroxyvitamin D concentrations in women with polycystic ovary syndrome (PCOS) compared with non-PCOS controls matched for body mass index. MATERIALS ANDMETHODS:
Three databases were searched (2003-2015) to retrieve studies that evaluated serum 25-hydroxyvitamin D in PCOS women and controls. Meta-regression analysis was performed with anthropometric and metabolic/endocrine parameters as covariates.RESULTS:
Fourteen studies that included 2262 women (1150 PCOS patients/1162 controls) were eligible. Serum 25-hydroxyvitamin D, follicle-stimulating hormone and sex hormone-binding globulin were significantly lower in patients with PCOS than controls. Homoeostatic model assessment-insulin resistance index, serum insulin, total cholesterol, triglycerides, low-density lipoprotein cholesterol, luteinising hormone and testosterone were significantly higher in patients with PCOS compared to controls. Meta-regression analysis demonstrated significant effects of waist-to-hip ratio and glucose in PCOS women (ß = -1·60, 95% CI -2·30 to -0·90, P = 0·003; ß = 0·20, 95% CI 0·80-0·32, P = 0·004, respectively) and controls (ß = -2·36, 95% CI -3·38 to -1·33, P = 0·003; ß = 0·11, 95% CI 0·00-0·21, P = 0·05, respectively) and of total calcium and luteinising hormone in PCOS cases (ß = 2·43, 95% CI 1·67-3·19, P = 0·005; ß = -0·37, 95% CI -0·68 to -0·06, P = 0·03, respectively).CONCLUSIONS:
Serum 25-hydroxyvitamin D may be predicted positively by serum calcium and negatively by luteinising hormone in women with PCOS, and negatively by waist-to-hip ratio and positively by fasting glucose in both PCOS and non-PCOS women, independently of the presence of obesity.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
/
Vitamina D
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Relação Cintura-Quadril
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
/
Systematic_reviews
Limite:
Female
/
Humans
Idioma:
En
Revista:
Eur J Clin Invest
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Grécia