Adenosine Deaminase (ADA)-Deficient Severe Combined Immune Deficiency (SCID): Molecular Pathogenesis and Clinical Manifestations.

Bradford, Kathryn L; Moretti, Federico A; Carbonaro-Sarracino, Denise A; Gaspar, Hubert B; Kohn, Donald B

Bradford, Kathryn L; Moretti, Federico A; Carbonaro-Sarracino, Denise A; Gaspar, Hubert B; Kohn, Donald B.

Afiliação

Bradford KL; Department of Pediatrics, University of California, Los Angeles (UCLA), 3163 Terasaki Life Science Bldg., 610 Charles E. Young Drive East, Los Angeles, CA, 90095, USA.
Moretti FA; Centre for Immunodeficiency, Molecular Immunology Unit, University College London Institute of Child Health, London, UK.
Carbonaro-Sarracino DA; Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, USA.
Gaspar HB; Centre for Immunodeficiency, Molecular Immunology Unit, University College London Institute of Child Health, London, UK.
Kohn DB; Department of Pediatrics, University of California, Los Angeles (UCLA), 3163 Terasaki Life Science Bldg., 610 Charles E. Young Drive East, Los Angeles, CA, 90095, USA. Dkohn1@mednet.ucla.edu.

J Clin Immunol ; 37(7): 626-637, 2017 Oct.

Article em En | MEDLINE | ID: mdl-28842866

Assuntos

Adenosina Desaminase/deficiência; Adenosina Desaminase/genética; Imunodeficiência Combinada Severa/genética; Animais; Modelos Animais de Doenças; Humanos

Palavras-chave

Adenosine Deaminase; Clinical trials; Gene therapy; Lymphopenia; Purine metabolism; SCID

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenosina Desaminase / Imunodeficiência Combinada Severa Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: J Clin Immunol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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