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Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation.
Scannevin, Robert H; Alexander, Richard; Haarlander, Tara Mezzasalma; Burke, Sharon L; Singer, Monica; Huo, Cuifen; Zhang, Yue-Mei; Maguire, Diane; Spurlino, John; Deckman, Ingrid; Carroll, Karen I; Lewandowski, Frank; Devine, Eric; Dzordzorme, Keli; Tounge, Brett; Milligan, Cindy; Bayoumy, Shariff; Williams, Robyn; Schalk-Hihi, Celine; Leonard, Kristi; Jackson, Paul; Todd, Matthew; Kuo, Lawrence C; Rhodes, Kenneth J.
Afiliação
  • Scannevin RH; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477 rscannevin@yumanity.com.
  • Alexander R; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Haarlander TM; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Burke SL; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Singer M; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Huo C; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Zhang YM; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Maguire D; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Spurlino J; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Deckman I; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Carroll KI; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Lewandowski F; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Devine E; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Dzordzorme K; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Tounge B; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Milligan C; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Bayoumy S; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Williams R; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Schalk-Hihi C; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Leonard K; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Jackson P; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Todd M; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Kuo LC; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
  • Rhodes KJ; From Janssen Research and Development, LLC, Spring House, Pennsylvania 19477.
J Biol Chem ; 292(43): 17963-17974, 2017 10 27.
Article em En | MEDLINE | ID: mdl-28860188
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Metaloproteinase 9 da Matriz / Precursores Enzimáticos / Inibidores de Metaloproteinases de Matriz Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Metaloproteinase 9 da Matriz / Precursores Enzimáticos / Inibidores de Metaloproteinases de Matriz Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article