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Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.
Molokie, Robert; Lavelle, Donald; Gowhari, Michel; Pacini, Michael; Krauz, Lani; Hassan, Johara; Ibanez, Vinzon; Ruiz, Maria A; Ng, Kwok Peng; Woost, Philip; Radivoyevitch, Tomas; Pacelli, Daisy; Fada, Sherry; Rump, Matthew; Hsieh, Matthew; Tisdale, John F; Jacobberger, James; Phelps, Mitch; Engel, James Douglas; Saraf, Santhosh; Hsu, Lewis L; Gordeuk, Victor; DeSimone, Joseph; Saunthararajah, Yogen.
Afiliação
  • Molokie R; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America.
  • Lavelle D; Jesse Brown VA Medical Center, Chicago, Illinois, United States of America.
  • Gowhari M; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America.
  • Pacini M; Jesse Brown VA Medical Center, Chicago, Illinois, United States of America.
  • Krauz L; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America.
  • Hassan J; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America.
  • Ibanez V; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America.
  • Ruiz MA; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America.
  • Ng KP; Jesse Brown VA Medical Center, Chicago, Illinois, United States of America.
  • Woost P; Jesse Brown VA Medical Center, Chicago, Illinois, United States of America.
  • Radivoyevitch T; Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.
  • Pacelli D; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America.
  • Fada S; Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, United States of America.
  • Rump M; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America.
  • Hsieh M; Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.
  • Tisdale JF; Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.
  • Jacobberger J; Molecular and Clinical Hematology Section, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Phelps M; Molecular and Clinical Hematology Section, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Engel JD; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America.
  • Saraf S; College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America.
  • Hsu LL; Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Gordeuk V; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America.
  • DeSimone J; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America.
  • Saunthararajah Y; Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America.
PLoS Med ; 14(9): e1002382, 2017 Sep.
Article em En | MEDLINE | ID: mdl-28880867
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Azacitidina / Tetra-Hidrouridina / Regulação da Expressão Gênica / Epigênese Genética / Inibidores Enzimáticos / Anemia Falciforme Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS Med Assunto da revista: MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Azacitidina / Tetra-Hidrouridina / Regulação da Expressão Gênica / Epigênese Genética / Inibidores Enzimáticos / Anemia Falciforme Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS Med Assunto da revista: MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos