An Analysis of the Relationship Between Preclinical and Clinical QT Interval-Related Data.

Pollard, Christopher E; Skinner, Matthew; Lazic, Stanley E; Prior, Helen M; Conlon, Kelly M; Valentin, Jean-Pierre; Dota, Corina

Pollard, Christopher E; Skinner, Matthew; Lazic, Stanley E; Prior, Helen M; Conlon, Kelly M; Valentin, Jean-Pierre; Dota, Corina.

Afiliação

Pollard CE; Safety and ADME Translational Sciences, Drug Safety and Metabolism.
Skinner M; Safety and ADME Translational Sciences, Drug Safety and Metabolism.
Lazic SE; Cardiovascular Centre of Excellence, Global Medicines Development, AstraZeneca R&D, Gothenburg 43183, Sweden.
Prior HM; Safety and ADME Translational Sciences, Drug Safety and Metabolism.
Conlon KM; Safety and ADME Translational Sciences, Drug Safety and Metabolism.
Valentin JP; Safety and ADME Translational Sciences, Drug Safety and Metabolism.
Dota C; Quantitative Biology, Discovery Sciences, Innovative Medicines and Early Development, AstraZeneca R&D, Cambridge CB4?0WG, UK.

Toxicol Sci ; 159(1): 94-101, 2017 09 01.

Article em En | MEDLINE | ID: mdl-28903488

Assuntos

Doenças do Cão/fisiopatologia; Eletrocardiografia; Síndrome do QT Longo/veterinária; Animais; Cães; Humanos; Síndrome do QT Longo/fisiopatologia; Técnicas de Patch-Clamp; Curva ROC

Palavras-chave

QT interval prolongation; hERG; preclinical to clinical translation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do QT Longo / Doenças do Cão / Eletrocardiografia Tipo de estudo: Guideline / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Toxicol Sci Assunto da revista: TOXICOLOGIA Ano de publicação: 2017 Tipo de documento: Article

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