Blood flow regulation and oxidative stress during submaximal cycling exercise in patients with cystic fibrosis.
J Cyst Fibros
; 17(2): 256-263, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-28923457
ABSTRACT
BACKGROUND:
The impact of blood flow regulation and oxidative stress during exercise in cystic fibrosis (CF) has yet to be investigated.METHODS:
A maximal graded exercise test was conducted to determine exercise capacity (VO2 peak) and peak workload in 14 pediatric patients with mild CF (age 14±3y, FEV1 93±16 % predicted) and 14 demographically-matched controls. On a separate visit, participants performed submaximal cycling up to 60% of peak workload where brachial artery blood velocity was determined using Doppler ultrasound. Retrograde and antegrade components were further analyzed as indices of blood flow regulation.RESULTS:
The cumulative AUC for retrograde velocity was lower in patients versus controls (1770±554 vs. 3440±522cm, P=0.038). In addition, an exaggerated oxidative stress response during exercise occurred in patients only (P=0.004).CONCLUSION:
These data suggest that patients with mild CF exhibit impaired blood flow regulation and an exaggerated oxidative stress response to submaximal exercise.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclismo
/
Velocidade do Fluxo Sanguíneo
/
Exercício Físico
/
Tolerância ao Exercício
/
Estresse Oxidativo
/
Fibrose Cística
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Cyst Fibros
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos