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Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus.
Hiwasa, Takaki; Zhang, Xiao-Meng; Kimura, Risa; Ohno, Mikiko; Chen, Po-Min; Nishi, Eiichiro; Ono, Koh; Kimura, Takeshi; Kamitsukasa, Ikuo; Wada, Takeshi; Aotsuka, Akiyo; Mine, Seiichiro; Takizawa, Hirotaka; Kashiwado, Koichi; Takemoto, Minoru; Kobayashi, Kazuki; Kawamura, Harukiyo; Ishibashi, Ryoichi; Yokote, Koutaro; Nakamura, Rika; Tomiyoshi, Go; Shinmen, Natsuko; Kuroda, Hideyuki.
Afiliação
  • Hiwasa T; Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Zhang XM; Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Kimura R; Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Ohno M; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Chen PM; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Nishi E; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Ono K; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Kimura T; Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Kamitsukasa I; Department of Neurology, Chiba Rosai Hospital, Chiba, Japan.
  • Wada T; Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan.
  • Aotsuka A; Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba, Japan.
  • Mine S; Department of Neurological Surgery, Chiba Prefectural Sawara Hospital, Chiba, Japan.
  • Takizawa H; Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Kashiwado K; Port Square Kashiwado Clinic, Kashiwado Memorial Foundation, Chiba, Japan.
  • Takemoto M; Department of Neurology, Kashiwado Hospital, Chiba, Japan.
  • Kobayashi K; Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Kawamura H; Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Ishibashi R; Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Yokote K; Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Nakamura R; Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Tomiyoshi G; Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Shinmen N; Medical Project Division, Research Development Center, Fujikura Kasei Co., Saitama, Japan.
  • Kuroda H; Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
J Circ Biomark ; 5: 8, 2016.
Article em En | MEDLINE | ID: mdl-28936256
ABSTRACT
Adiponectin secreted from the adipocytes plays pleiotropic, anti-atherosclerotic roles, such as enhancement of insulin secretion and an increase in energy expenditure. The measurement of levels of circulating adiponectin is useful to evaluate the progression of atherosclerosis-related diseases, such as coronary artery disease (CAD), cerebral infarction (CI) and diabetes mellitus (DM). We examined the serum antibody levels against recombinant adiponectin protein via the amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA) method. The results revealed that the antibody levels were significantly higher in patients with CAD, CI and type 2 DM, than in healthy donors. Receiver operating curve analysis showed that the sensitivity was in a range of 41-48% for CAD, CI and DM. Thus, the serum anti-adiponectin antibody levels could be a common marker for atherosclerosis-related diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Circ Biomark Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Circ Biomark Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão