A peripherally restricted P2Y12 receptor antagonist altered rat tumor incidences with no human relevance: Mode of action consistent with dopamine agonism.
Toxicol Rep
; 1: 1202-1212, 2014.
Article
em En
| MEDLINE
| ID: mdl-28962330
ADP, adenosine-5'-diphosphate; AUC, area under the curve; CHO, Chinese hamster ovary; Carcinogenicity; Cmax, maximal concentration, DAT, dopamine transport; Dopamine transport inhibitor; E2, estradiol; GLP, good laboratory practice; H&E, hematoxylin and eosin; IC50, inhibitory concentration fifty percent; Ki, inhibition concentration; LC-MS/MS, liquid chromatography-mass spectrometric; LLOQ, lower limits of quantification; MOA, mode of action; MTD, maximum tolerated dose; NH, Hill coefficient; Prolactin; QWBA, quantitative whole body autoradiography; TK, toxicokinetics; Translational; Uterine tumor
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Idioma:
En
Revista:
Toxicol Rep
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos