A peripherally restricted P2Y<sub>12</sub> receptor antagonist altered rat tumor incidences with no human relevance: Mode of action consistent with dopamine agonism.

Brott, David A; Andersson, Håkan A S; Stewart, Jane; Ewart, Lorna; Christoph, Greg; Harleman, Johannes; Armstrong, Duncan; Kinter, Lewis B

A peripherally restricted P2Y₁₂ receptor antagonist altered rat tumor incidences with no human relevance: Mode of action consistent with dopamine agonism.

Brott, David A; Andersson, Håkan A S; Stewart, Jane; Ewart, Lorna; Christoph, Greg; Harleman, Johannes; Armstrong, Duncan; Kinter, Lewis B.

Afiliação

Brott DA; Drug Safety & Metabolism, AstraZeneca Pharmaceuticals, R&D, Wilmington, DE, USA.
Andersson HAS; Drug Safety & Metabolism, AstraZeneca, R&D, Södertälje, Sweden.
Stewart J; Drug Safety & Metabolism, AstraZeneca Pharmaceuticals, R&D, Alderley Park, UK.
Ewart L; Drug Safety & Metabolism, AstraZeneca Pharmaceuticals, R&D, Alderley Park, UK.
Christoph G; Drug Safety & Metabolism, AstraZeneca Pharmaceuticals, R&D, Wilmington, DE, USA.
Harleman J; Drug Safety & Metabolism, AstraZeneca Pharmaceuticals, R&D, Alderley Park, UK.
Armstrong D; Drug Safety & Metabolism, AstraZeneca Pharmaceuticals, R&D, Alderley Park, UK.
Kinter LB; Drug Safety & Metabolism, AstraZeneca Pharmaceuticals, R&D, Wilmington, DE, USA.

Toxicol Rep ; 1: 1202-1212, 2014.

Article em En | MEDLINE | ID: mdl-28962330

Palavras-chave

ADP, adenosine-5'-diphosphate; AUC, area under the curve; CHO, Chinese hamster ovary; Carcinogenicity; Cmax, maximal concentration, DAT, dopamine transport; Dopamine transport inhibitor; E2, estradiol; GLP, good laboratory practice; H&E, hematoxylin and eosin; IC50, inhibitory concentration fifty percent; Ki, inhibition concentration; LC-MS/MS, liquid chromatography-mass spectrometric; LLOQ, lower limits of quantification; MOA, mode of action; MTD, maximum tolerated dose; NH, Hill coefficient; Prolactin; QWBA, quantitative whole body autoradiography; TK, toxicokinetics; Translational; Uterine tumor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Qualitative_research / Risk_factors_studies Idioma: En Revista: Toxicol Rep Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos

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