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Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.
Nakatani, Yoshio; Opel-Reading, Helen K; Merker, Matthias; Machado, Diana; Andres, Sönke; Kumar, S Siva; Moradigaravand, Danesh; Coll, Francesc; Perdigão, João; Portugal, Isabel; Schön, Thomas; Nair, Dina; Devi, K R Uma; Kohl, Thomas A; Beckert, Patrick; Clark, Taane G; Maphalala, Gugu; Khumalo, Derrick; Diel, Roland; Klaos, Kadri; Aung, Htin Lin; Cook, Gregory M; Parkhill, Julian; Peacock, Sharon J; Swaminathan, Soumya; Viveiros, Miguel; Niemann, Stefan; Krause, Kurt L; Köser, Claudio U.
Afiliação
  • Nakatani Y; Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
  • Opel-Reading HK; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.
  • Merker M; Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
  • Machado D; Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
  • Andres S; Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
  • Kumar SS; German Center for Infection Research, Partner Site Hamburg-Borstel-Lübeck, Germany.
  • Moradigaravand D; Unidade de Microbiologia Médica, Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal.
  • Coll F; Division of Mycobacteriology (National Tuberculosis Reference Laboratory), Research Center Borstel, Borstel, Germany.
  • Perdigão J; National Institute for Research in Tuberculosis, Chennai, India.
  • Portugal I; Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
  • Schön T; London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Nair D; Med.ULisboa-Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal.
  • Devi KRU; Med.ULisboa-Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal.
  • Kohl TA; Department of Clinical and Experimental Medicine, Division of Medical Microbiology, Linköping University, Linköping, Sweden.
  • Beckert P; Department of Clinical Microbiology and Infectious Diseases, Kalmar County Hospital, Kalmar, Sweden.
  • Clark TG; National Institute for Research in Tuberculosis, Chennai, India.
  • Maphalala G; National Institute for Research in Tuberculosis, Chennai, India.
  • Khumalo D; Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
  • Diel R; Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
  • Klaos K; German Center for Infection Research, Partner Site Hamburg-Borstel-Lübeck, Germany.
  • Aung HL; London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Cook GM; National Reference Laboratory, Ministry of Health, Mbabane, Swaziland.
  • Parkhill J; National Tuberculosis Control Program, Ministry of Health, Manzini, Swaziland.
  • Peacock SJ; Institute of Epidemiology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
  • Swaminathan S; Tartu University Hospital, United Laboratories, Mycobacteriology, Tartu, Estonia.
  • Viveiros M; Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
  • Niemann S; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.
  • Krause KL; Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand.
  • Köser CU; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.
Antimicrob Agents Chemother ; 61(12)2017 12.
Article em En | MEDLINE | ID: mdl-28971867
ABSTRACT
A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d-cycloserine.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Ciclosserina / Farmacorresistência Bacteriana / Alanina Racemase / Mutação / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Nova Zelândia
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Ciclosserina / Farmacorresistência Bacteriana / Alanina Racemase / Mutação / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Nova Zelândia