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Proof of Concept Coded Aperture Miniature Mass Spectrometer Using a Cycloidal Sector Mass Analyzer, a Carbon Nanotube (CNT) Field Emission Electron Ionization Source, and an Array Detector.
Amsden, Jason J; Herr, Philip J; Landry, David M W; Kim, William; Vyas, Raul; Parker, Charles B; Kirley, Matthew P; Keil, Adam D; Gilchrist, Kristin H; Radauscher, Erich J; Hall, Stephen D; Carlson, James B; Baldasaro, Nicholas; Stokes, David; Di Dona, Shane T; Russell, Zachary E; Grego, Sonia; Edwards, Steven J; Sperline, Roger P; Denton, M Bonner; Stoner, Brian R; Gehm, Michael E; Glass, Jeffrey T.
Afiliação
  • Amsden JJ; Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA.
  • Herr PJ; Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA.
  • Landry DMW; Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA.
  • Kim W; Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA.
  • Vyas R; Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA.
  • Parker CB; Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA.
  • Kirley MP; Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA.
  • Keil AD; Broadway Analytical, LLC, Monmouth, IL, 61462, USA.
  • Gilchrist KH; Engineering and Applied Physics Division, RTI International, Research Triangle Park, NC, 27709, USA.
  • Radauscher EJ; Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA.
  • Hall SD; Engineering and Applied Physics Division, RTI International, Research Triangle Park, NC, 27709, USA.
  • Carlson JB; Engineering and Applied Physics Division, RTI International, Research Triangle Park, NC, 27709, USA.
  • Baldasaro N; Engineering and Applied Physics Division, RTI International, Research Triangle Park, NC, 27709, USA.
  • Stokes D; Engineering and Applied Physics Division, RTI International, Research Triangle Park, NC, 27709, USA.
  • Di Dona ST; Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA.
  • Russell ZE; Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA.
  • Grego S; Ion Innovations, Peachtree Corners, GA, 30092, USA.
  • Edwards SJ; Engineering and Applied Physics Division, RTI International, Research Triangle Park, NC, 27709, USA.
  • Sperline RP; Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, 85721, USA.
  • Denton MB; Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, 85721, USA.
  • Stoner BR; Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, 85721, USA.
  • Gehm ME; Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA.
  • Glass JT; Engineering and Applied Physics Division, RTI International, Research Triangle Park, NC, 27709, USA.
J Am Soc Mass Spectrom ; 29(2): 360-372, 2018 02.
Article em En | MEDLINE | ID: mdl-29052038
ABSTRACT
Despite many potential applications, miniature mass spectrometers have had limited adoption in the field due to the tradeoff between throughput and resolution that limits their performance relative to laboratory instruments. Recently, a solution to this tradeoff has been demonstrated by using spatially coded apertures in magnetic sector mass spectrometers, enabling throughput and signal-to-background improvements of greater than an order of magnitude with no loss of resolution. This paper describes a proof of concept demonstration of a cycloidal coded aperture miniature mass spectrometer (C-CAMMS) demonstrating use of spatially coded apertures in a cycloidal sector mass analyzer for the first time. C-CAMMS also incorporates a miniature carbon nanotube (CNT) field emission electron ionization source and a capacitive transimpedance amplifier (CTIA) ion array detector. Results confirm the cycloidal mass analyzer's compatibility with aperture coding. A >10× increase in throughput was achieved without loss of resolution compared with a single slit instrument. Several areas where additional improvement can be realized are identified. Graphical Abstract ᅟ.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Am Soc Mass Spectrom Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Am Soc Mass Spectrom Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos