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Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.
McClure, Kim F; Piotrowski, David W; Petersen, Donna; Wei, Liuqing; Xiao, Jun; Londregan, Allyn T; Kamlet, Adam S; Dechert-Schmitt, Anne-Marie; Raymer, Brian; Ruggeri, Roger B; Canterbury, Daniel; Limberakis, Chris; Liras, Spiros; DaSilva-Jardine, Paul; Dullea, Robert G; Loria, Paula M; Reidich, Benjamin; Salatto, Christopher T; Eng, Heather; Kimoto, Emi; Atkinson, Karen; King-Ahmad, Amanda; Scott, Dennis; Beaumont, Kevin; Chabot, Jeffrey R; Bolt, Michael W; Maresca, Kevin; Dahl, Kenneth; Arakawa, Ryosuke; Takano, Akihiro; Halldin, Christer.
Afiliação
  • McClure KF; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Piotrowski DW; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Petersen D; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Wei L; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Xiao J; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Londregan AT; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Kamlet AS; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Dechert-Schmitt AM; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Raymer B; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Ruggeri RB; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Canterbury D; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Limberakis C; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Liras S; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Dullea RG; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Loria PM; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Reidich B; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Salatto CT; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Eng H; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Kimoto E; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Atkinson K; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • King-Ahmad A; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Scott D; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Beaumont K; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Chabot JR; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Bolt MW; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Maresca K; Department of Medicinal Chemistry, Pfizer Inc, 1 Portland Street, Cambridge, MA, 02139, USA.
  • Dahl K; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.
  • Arakawa R; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.
  • Takano A; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.
  • Halldin C; Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.
Angew Chem Int Ed Engl ; 56(51): 16218-16222, 2017 12 18.
Article em En | MEDLINE | ID: mdl-29073340
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bibliotecas de Moléculas Pequenas / Pró-Proteína Convertase 9 / Inibidores de PCSK9 / Fígado Limite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bibliotecas de Moléculas Pequenas / Pró-Proteína Convertase 9 / Inibidores de PCSK9 / Fígado Limite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos