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GA101 P329GLALA, a variant of obinutuzumab with abolished ADCC, ADCP and CDC function but retained cell death induction, is as efficient as rituximab in B-cell depletion and antitumor activity.
Herter, Sylvia; Herting, Frank; Muth, Gunter; van Puijenbroek, Erwin; Schlothauer, Tilman; Ferrara, Claudia; Brady, Kevin; Lang, Sabine; Bacac, Marina; Mössner, Ekkehard; Umana, Pablo; Klein, Christian.
Afiliação
  • Herter S; Roche Pharmaceutical Research & Early Development, 1Roche Innovation Center Zurich, Switzerland.
  • Herting F; Roche Innovation Center Munich, Germany.
  • Muth G; Roche Innovation Center Munich, Germany.
  • van Puijenbroek E; Roche Pharmaceutical Research & Early Development, 1Roche Innovation Center Zurich, Switzerland.
  • Schlothauer T; Roche Innovation Center Munich, Germany.
  • Ferrara C; Roche Pharmaceutical Research & Early Development, 1Roche Innovation Center Zurich, Switzerland.
  • Brady K; Roche Innovation Center Basel, Switzerland.
  • Lang S; Roche Pharmaceutical Research & Early Development, 1Roche Innovation Center Zurich, Switzerland.
  • Bacac M; Roche Pharmaceutical Research & Early Development, 1Roche Innovation Center Zurich, Switzerland.
  • Mössner E; Roche Pharmaceutical Research & Early Development, 1Roche Innovation Center Zurich, Switzerland.
  • Umana P; Roche Pharmaceutical Research & Early Development, 1Roche Innovation Center Zurich, Switzerland.
  • Klein C; Roche Pharmaceutical Research & Early Development, 1Roche Innovation Center Zurich, Switzerland christian.klein.ck1@roche.com.
Haematologica ; 103(2): e78-e81, 2018 02.
Article em En | MEDLINE | ID: mdl-29079598
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Morte Celular / Anticorpos Monoclonais Humanizados / Rituximab / Antineoplásicos Limite: Humans Idioma: En Revista: Haematologica Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Suíça
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Morte Celular / Anticorpos Monoclonais Humanizados / Rituximab / Antineoplásicos Limite: Humans Idioma: En Revista: Haematologica Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Suíça