The Sec61/SecY complex is inherently deficient in translocating intrinsically disordered proteins.

Gonsberg, Anika; Jung, Sebastian; Ulbrich, Sarah; Origi, Andrea; Ziska, Anke; Baier, Michael; Koch, Hans-Georg; Zimmermann, Richard; Winklhofer, Konstanze F; Tatzelt, Jörg

Gonsberg, Anika; Jung, Sebastian; Ulbrich, Sarah; Origi, Andrea; Ziska, Anke; Baier, Michael; Koch, Hans-Georg; Zimmermann, Richard; Winklhofer, Konstanze F; Tatzelt, Jörg.

Afiliação

Gonsberg A; From the Departments of Biochemistry of Neurodegenerative Diseases and.
Jung S; From the Departments of Biochemistry of Neurodegenerative Diseases and.
Ulbrich S; From the Departments of Biochemistry of Neurodegenerative Diseases and.
Origi A; the Institute of Biochemistry and Molecular Biology, Faculty of Medicine, Albert-Ludwigs-University Freiburg, D-79104 Freiburg im Breisgau, Germany.
Ziska A; the Department of Medical Biochemistry and Molecular Biology, Saarland University, D-66421 Homburg, Germany, and.
Baier M; the Research Group Proteinopathies/Neurodegenerative Diseases, Centre for Biological Threats and Special Pathogens, Robert Koch-Institut, D-13353 Berlin, Germany.
Koch HG; the Institute of Biochemistry and Molecular Biology, Faculty of Medicine, Albert-Ludwigs-University Freiburg, D-79104 Freiburg im Breisgau, Germany.
Zimmermann R; the Department of Medical Biochemistry and Molecular Biology, Saarland University, D-66421 Homburg, Germany, and.
Winklhofer KF; Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, D-44801 Bochum, Germany.
Tatzelt J; From the Departments of Biochemistry of Neurodegenerative Diseases and Joerg.Tatzelt@rub.de.

J Biol Chem ; 292(52): 21383-21396, 2017 12 29.

Article em En | MEDLINE | ID: mdl-29084847

Assuntos

Canais de Translocação SEC/metabolismo; Canais de Translocação SEC/fisiologia; Membrana Celular/metabolismo; Retículo Endoplasmático/metabolismo; Escherichia coli/metabolismo; Proteínas de Escherichia coli/metabolismo; Células HeLa; Humanos; Proteínas de Membrana/metabolismo; Proteínas de Membrana Transportadoras/metabolismo; Peptídeos/metabolismo; Estrutura Secundária de Proteína; Transporte Proteico; Canais de Translocação SEC/genética; Saccharomyces cerevisiae/metabolismo; Proteínas de Saccharomyces cerevisiae/metabolismo

Palavras-chave

ER import; Sec61; SecY; endoplasmic reticulum (ER); intrinsically disordered protein; prion; protein secretion; protein translocation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canais de Translocação SEC Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article

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