Association of COL1A1 rs1800012 polymorphism with musculoskeletal degenerative diseases: a meta-analysis.
Oncotarget
; 8(43): 75488-75499, 2017 Sep 26.
Article
em En
| MEDLINE
| ID: mdl-29088884
ABSTRACT
It has been reported that the single nucleotide polymorphism (SNP) rs1800012 in COL1A1 gene might be linked to the susceptibility of musculoskeletal degenerative diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IVDD). However, the data from different studies is contradictory. Here we aimed to comprehensively summarize and clarify the relationship between the SNP and musculoskeletal degenerative diseases. Seven eligible studies including 1339 cases and 5406 controls were screened out from PubMed, Web Of Science and Cochrane library databases. Significant association was identified in sub group analysis of IVDD in homozygote model (GG versus TT OR = 0.33, 95% CI 0.14-0.78, P = 0.012), heterozygote model (GT versus TT OR = 0.29, 95% CI 0.11-0.72, P = 0.008) and dominant model (GG/GT versus TT OR = 0.31, 95% CI 0.13-0.74, P = 0.008). Additionally, significant relationship was also found in sub group analysis of severe degree of IVDD in homozygote model (GG versus TT OR = 0.37, 95% CI 0.15-0.91, P = 0.031), heterozygote model (GT versus TT OR = 0.33, 95% CI 0.13-0.87,P = 0.024) and dominant model (GG/GT versus TT OR = 0.36, 95% CI 0.14-0.88, P = 0.025). Although no significance was observed, there is a trend that the more G allele at COL1A1 rs1800012 site, the less possibility of IVDD and severe IVDD would happen. Our results indicate that COL1A1 rs1800012 polymorphism associates with the susceptibility of IVDD. However, this polymorphism may not be associated with OA risk.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Risk_factors_studies
/
Systematic_reviews
Idioma:
En
Revista:
Oncotarget
Ano de publicação:
2017
Tipo de documento:
Article