"On Water" Direct C-3 Arylation of 2H-Pyrazolo[3,4-b]pyridines.

Faarasse, Soukaina; El Kazzouli, Saïd; Naas, Mohammed; Jouha, Jabrane; Suzenet, Franck; Guillaumet, Gérald

Faarasse, Soukaina; El Kazzouli, Saïd; Naas, Mohammed; Jouha, Jabrane; Suzenet, Franck; Guillaumet, Gérald.

Afiliação

Faarasse S; Euromed Faculty of Engineering, Euromed University of Fes (UEMF) , Route de Meknès, 30000 Fès, Morocco.
El Kazzouli S; Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans, UMR CNRS , 7311 BP 6759, 45067 Orléans Cedex 2, France.
Naas M; Euromed Faculty of Engineering, Euromed University of Fes (UEMF) , Route de Meknès, 30000 Fès, Morocco.
Jouha J; Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans, UMR CNRS , 7311 BP 6759, 45067 Orléans Cedex 2, France.
Suzenet F; Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans, UMR CNRS , 7311 BP 6759, 45067 Orléans Cedex 2, France.
Guillaumet G; Institut de Chimie Organique et Analytique (ICOA), Université d'Orléans, UMR CNRS , 7311 BP 6759, 45067 Orléans Cedex 2, France.

J Org Chem ; 82(23): 12300-12306, 2017 12 01.

Article em En | MEDLINE | ID: mdl-29090922

RESUMO

An "on water" palladium-catalyzed direct (hetero)arylation of 2H-pyrazolo[3,4-b]pyridines has been developed. The reactions proceeds smoothly with at low catalytic loading at low temperature providing the C3 (hetero)arylated products in good to excellent isolated yields. Free NH 3-arylated 7-azaindazoles were also prepared by simple cleavage of the N-protected groups.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Marrocos

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