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Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase.
Butler, Christopher R; Beck, Elizabeth M; Harris, Anthony; Huang, Zhen; McAllister, Laura A; Am Ende, Christopher W; Fennell, Kimberly; Foley, Timothy L; Fonseca, Kari; Hawrylik, Steven J; Johnson, Douglas S; Knafels, John D; Mente, Scot; Noell, G Stephen; Pandit, Jayvardhan; Phillips, Tracy B; Piro, Justin R; Rogers, Bruce N; Samad, Tarek A; Wang, Jane; Wan, Shuangyi; Brodney, Michael A.
Afiliação
  • Butler CR; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Beck EM; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Harris A; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States.
  • Huang Z; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • McAllister LA; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Am Ende CW; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States.
  • Fennell K; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States.
  • Foley TL; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States.
  • Fonseca K; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Hawrylik SJ; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States.
  • Johnson DS; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Knafels JD; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States.
  • Mente S; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Noell GS; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States.
  • Pandit J; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States.
  • Phillips TB; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States.
  • Piro JR; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Rogers BN; Pfizer Worldwide Research and Development , 445 Eastern Point Road, Groton, Connecticut 06340, United States.
  • Samad TA; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Wang J; WuXi AppTec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
  • Wan S; WuXi AppTec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
  • Brodney MA; Pfizer Worldwide Research and Development , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
J Med Chem ; 60(23): 9860-9873, 2017 12 14.
Article em En | MEDLINE | ID: mdl-29148769
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Azetidinas / Carbamatos / Inibidores Enzimáticos / Monoacilglicerol Lipases Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Azetidinas / Carbamatos / Inibidores Enzimáticos / Monoacilglicerol Lipases Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos