Your browser doesn't support javascript.
loading
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma.
Scott, James S; Degorce, Sébastien L; Anjum, Rana; Culshaw, Janet; Davies, Robert D M; Davies, Nichola L; Dillman, Keith S; Dowling, James E; Drew, Lisa; Ferguson, Andrew D; Groombridge, Sam D; Halsall, Christopher T; Hudson, Julian A; Lamont, Scott; Lindsay, Nicola A; Marden, Stacey K; Mayo, Michele F; Pease, J Elizabeth; Perkins, David R; Pink, Jennifer H; Robb, Graeme R; Rosen, Alan; Shen, Minhui; McWhirter, Claire; Wu, Dedong.
Afiliação
  • Scott JS; Oncology, IMED Biotech Unit, AstraZeneca , Cambridge CB4 0FZ, United Kingdom.
  • Degorce SL; Oncology, IMED Biotech Unit, AstraZeneca , Cambridge CB4 0FZ, United Kingdom.
  • Anjum R; Oncology, IMED Biotech Unit, AstraZeneca , Boston, Massachusetts 02451, United States.
  • Culshaw J; Oncology, IMED Biotech Unit, AstraZeneca , Macclesfield SK10 4TG, United Kingdom.
  • Davies RDM; Oncology, IMED Biotech Unit, AstraZeneca , Macclesfield SK10 4TG, United Kingdom.
  • Davies NL; Oncology, IMED Biotech Unit, AstraZeneca , Cambridge CB4 0FZ, United Kingdom.
  • Dillman KS; Oncology, IMED Biotech Unit, AstraZeneca , Boston, Massachusetts 02451, United States.
  • Dowling JE; Oncology, IMED Biotech Unit, AstraZeneca , Boston, Massachusetts 02451, United States.
  • Drew L; Oncology, IMED Biotech Unit, AstraZeneca , Boston, Massachusetts 02451, United States.
  • Ferguson AD; Oncology, IMED Biotech Unit, AstraZeneca , Boston, Massachusetts 02451, United States.
  • Groombridge SD; Oncology, IMED Biotech Unit, AstraZeneca , Macclesfield SK10 4TG, United Kingdom.
  • Halsall CT; Oncology, IMED Biotech Unit, AstraZeneca , Macclesfield SK10 4TG, United Kingdom.
  • Hudson JA; Oncology, IMED Biotech Unit, AstraZeneca , Macclesfield SK10 4TG, United Kingdom.
  • Lamont S; Oncology, IMED Biotech Unit, AstraZeneca , Cambridge CB4 0FZ, United Kingdom.
  • Lindsay NA; Oncology, IMED Biotech Unit, AstraZeneca , Cambridge CB4 0FZ, United Kingdom.
  • Marden SK; Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca , Boston, Massachusetts 02451, United States.
  • Mayo MF; Oncology, IMED Biotech Unit, AstraZeneca , Boston, Massachusetts 02451, United States.
  • Pease JE; Oncology, IMED Biotech Unit, AstraZeneca , Cambridge CB4 0FZ, United Kingdom.
  • Perkins DR; Oncology, IMED Biotech Unit, AstraZeneca , Macclesfield SK10 4TG, United Kingdom.
  • Pink JH; Oncology, IMED Biotech Unit, AstraZeneca , Macclesfield SK10 4TG, United Kingdom.
  • Robb GR; Oncology, IMED Biotech Unit, AstraZeneca , Cambridge CB4 0FZ, United Kingdom.
  • Rosen A; Oncology, IMED Biotech Unit, AstraZeneca , Boston, Massachusetts 02451, United States.
  • Shen M; Oncology, IMED Biotech Unit, AstraZeneca , Boston, Massachusetts 02451, United States.
  • McWhirter C; Oncology, IMED Biotech Unit, AstraZeneca , Cambridge CB4 0FZ, United Kingdom.
  • Wu D; Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca , Boston, Massachusetts 02451, United States.
J Med Chem ; 60(24): 10071-10091, 2017 12 28.
Article em En | MEDLINE | ID: mdl-29172502
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfoma Difuso de Grandes Células B / Inibidores de Proteínas Quinases / Quinases Associadas a Receptores de Interleucina-1 / Antineoplásicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfoma Difuso de Grandes Células B / Inibidores de Proteínas Quinases / Quinases Associadas a Receptores de Interleucina-1 / Antineoplásicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido