Amygdala Inhibitory Circuits Regulate Associative Fear Conditioning.
Biol Psychiatry
; 83(10): 800-809, 2018 05 15.
Article
em En
| MEDLINE
| ID: mdl-29174478
ABSTRACT
Associative memory formation is essential for an animal's survival by ensuring adaptive behavioral responses in an ever-changing environment. This is particularly important under conditions of immediate threats such as in fear learning. One of the key brain regions involved in associative fear learning is the amygdala. The basolateral amygdala is the main entry site for sensory information to the amygdala complex, and local plasticity in excitatory basolateral amygdala principal neurons is considered to be crucial for learning of conditioned fear responses. However, activity and plasticity of excitatory circuits are tightly controlled by local inhibitory interneurons in a spatially and temporally defined manner. In this review, we provide an updated view on how distinct interneuron subtypes in the basolateral amygdala contribute to the acquisition and extinction of conditioned fear memories.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Condicionamento Psicológico
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Medo
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Tonsila do Cerebelo
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Rede Nervosa
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Inibição Neural
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
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Humans
Idioma:
En
Revista:
Biol Psychiatry
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Suíça