Predictors of sleepiness in obstructive sleep apnoea at baseline and after 6â
months of continuous positive airway pressure therapy.
Eur Respir J
; 50(5)2017 11.
Article
em En
| MEDLINE
| ID: mdl-29191951
ABSTRACT
We evaluated factors associated with subjective and objective sleepiness at baseline and after 6â
months of continuous positive airway pressure (CPAP) therapy in patients with obstructive sleep apnoea (OSA).We analysed data from the Apnoea Positive Pressure Long-term Efficacy Study (APPLES), a prospective 6-month multicentre randomised controlled trial with 1105 subjects with OSA, 558 of who were randomised to active CPAP. Epworth sleepiness scale (ESS) scores and the mean sleep latency (MSL) on the maintenance of wakefulness test at baseline and after 6â
months of CPAP therapy were recorded.Excessive sleepiness (ESS score >10) was present in 543 (49.1%) participants. Younger age, presence of depression and higher apnoea-hypopnoea index were all associated with higher ESS scores and lower MSL. Randomisation to the CPAP group was associated with lower odds of sleepiness at 6â
months. The prevalence of sleepiness was significantly lower in those using CPAP >4â
h·night-1versus using CPAP ≤4â
h·night-1 Among those with good CPAP adherence, those with ESS >10 at baseline had significantly higher odds (OR 8.2, p<0.001) of persistent subjective sleepiness.Lower average nightly CPAP use and presence of sleepiness at baseline were independently associated with excessive subjective and objective sleepiness after 6â
months of CPAP therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vigília
/
Apneia Obstrutiva do Sono
/
Pressão Positiva Contínua nas Vias Aéreas
/
Distúrbios do Sono por Sonolência Excessiva
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur Respir J
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos