Association between a functional interleukin 6 receptor genetic variant and risk of depression and psychosis in a population-based birth cohort.

Khandaker, Golam M; Zammit, Stanley; Burgess, Stephen; Lewis, Glyn; Jones, Peter B

Khandaker, Golam M; Zammit, Stanley; Burgess, Stephen; Lewis, Glyn; Jones, Peter B.

Afiliação

Khandaker GM; Department of Psychiatry, University of Cambridge, Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK. Electronic address: gmk24@medschl.cam.ac.uk.
Zammit S; Centre for Mental Health, Addiction and Suicide Research, School of Social and Community Medicine, University of Bristol, Bristol, UK; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Burgess S; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Lewis G; Division of Psychiatry, University College London, London, UK.
Jones PB; Department of Psychiatry, University of Cambridge, Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.

Brain Behav Immun ; 69: 264-272, 2018 03.

Article em En | MEDLINE | ID: mdl-29197507

Assuntos

Transtorno Depressivo/genética; Polimorfismo de Nucleotídeo Único; Transtornos Psicóticos/genética; Receptores de Interleucina-6/genética; Adolescente; Proteína C-Reativa/metabolismo; Criança; Estudos de Coortes; Transtorno Depressivo/diagnóstico; Feminino; Predisposição Genética para Doença; Genótipo; Humanos; Interleucina-6/sangue; Masculino; Transtornos Psicóticos/diagnóstico

Palavras-chave

ALSPAC birth cohort; Asp358Ala; Depression; IL-6; IL6R; Immunopsychiatry; Inflammation; Interleukin 6; Interleukin 6 receptor; Interleukin 6 receptor gene; Mendelian randomization; Psychosis; rs2228145

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Receptores de Interleucina-6 / Polimorfismo de Nucleotídeo Único / Transtorno Depressivo Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Brain Behav Immun Assunto da revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Ano de publicação: 2018 Tipo de documento: Article

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