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Shear-Thinning and Thermo-Reversible Nanoengineered Inks for 3D Bioprinting.
Wilson, Scott A; Cross, Lauren M; Peak, Charles W; Gaharwar, Akhilesh K.
Afiliação
  • Wilson SA; Department of Biomedical Engineering, ‡Department of Material Sciences, and §Center for Remote Health Technologies and Systems, Texas A&M University , College Station, Texas 77843, United States.
  • Cross LM; Department of Biomedical Engineering, ‡Department of Material Sciences, and §Center for Remote Health Technologies and Systems, Texas A&M University , College Station, Texas 77843, United States.
  • Peak CW; Department of Biomedical Engineering, ‡Department of Material Sciences, and §Center for Remote Health Technologies and Systems, Texas A&M University , College Station, Texas 77843, United States.
  • Gaharwar AK; Department of Biomedical Engineering, ‡Department of Material Sciences, and §Center for Remote Health Technologies and Systems, Texas A&M University , College Station, Texas 77843, United States.
ACS Appl Mater Interfaces ; 9(50): 43449-43458, 2017 Dec 20.
Article em En | MEDLINE | ID: mdl-29214803
Three-dimensional (3D) printing is an emerging approach for rapid fabrication of complex tissue structures using cell-loaded bioinks. However, 3D bioprinting has hit a bottleneck in progress because of the lack of suitable bioinks that are printable, have high shape fidelity, and are mechanically resilient. In this study, we introduce a new family of nanoengineered bioinks consisting of kappa-carrageenan (κCA) and two-dimensional (2D) nanosilicates (nSi). κCA is a biocompatible, linear, sulfated polysaccharide derived from red algae and can undergo thermo-reversible and ionic gelation. The shear-thinning characteristics of κCA were tailored by nanosilicates to develop a printable bioink. By tuning κCA-nanosilicate ratios, the thermo-reversible gelation of the bioink can be controlled to obtain high printability and shape retention characteristics. The unique aspect of the nanoengineered κCA-nSi bioink is its ability to print physiologically-relevant-scale tissue constructs without requiring secondary supports. We envision that nanoengineered κCA-nanosilicate bioinks can be used to 3D print complex, large-scale, cell-laden tissue constructs with high structural fidelity and tunable mechanical stiffness for regenerative medicine.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bioimpressão Idioma: En Revista: ACS Appl Mater Interfaces Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bioimpressão Idioma: En Revista: ACS Appl Mater Interfaces Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos