18F-fluorodeoxyglucose specimen-positron emission mammography delineates tumour extension in breast-conserving surgery: Preliminary results.
Eur Radiol
; 28(5): 1929-1937, 2018 May.
Article
em En
| MEDLINE
| ID: mdl-29218614
ABSTRACT
OBJECTIVES:
We aimed to determine whether high-resolution specimen-positron emission mammography (PEM) using fluorodeoxyglucose (18F-FDG) can reveal extension of breast cancer in breast-conserving surgery (BCS), and assess the safety of radiation exposure to medical staff.METHODS:
Sixteen patients underwent positron emission tomography, and then BCS with intraoperative frozen section analysis on the same day. Resected specimens with remaining 18F-FDG accumulation were scanned by high-resolution PEM. At least 1 day after surgery, tumour extension was evaluated by three independent experienced readers and by binarized images from the specimen-PEM data. Intraoperative exposure of medical staff to 18F-FDG was measured.RESULTS:
Specimen-PEM evaluations of binarized images and the three investigators detected all (100 %, 12/12) invasive lesions and 94.4 % (17/18) of in situ lesions using both methods. The positive predictive value of the accumulated lesions was 74.4 % (29/39) for the binarized images and 82.9 % (29/35) for the three investigators. Analysis of intraoperative frozen sections detected 100 % (2/2) of the margin-positive cases, also detected by both specimen-PEM evaluation methods with no false-positive margin cases. The mean exposure of the medical staff to 18F was 18 µSv.CONCLUSIONS:
Specimen-PEM detected invasive and in situ lesions with high accuracy and allowable radiation exposure. KEY POINTS ⢠Specimen-PEM detected invasive and in situ lesions with high accuracy. ⢠Specimen-PEM predicted complete resection with the same accuracy as frozen section analysis. ⢠Breast-conserving surgery after fluorodeoxyglucose injection was performed with low medical staff exposure.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Mamografia
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Mastectomia Segmentar
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Fluordesoxiglucose F18
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Tomografia por Emissão de Pósitrons
Tipo de estudo:
Prognostic_studies
Limite:
Aged
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Eur Radiol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão