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Macrocyclization of Interferon-Poly(α-amino acid) Conjugates Significantly Improves the Tumor Retention, Penetration, and Antitumor Efficacy.
Hou, Yingqin; Zhou, Yu; Wang, Hao; Wang, Ruijue; Yuan, Jingsong; Hu, Yali; Sheng, Kai; Feng, Juan; Yang, Shengtao; Lu, Hua.
Afiliação
  • Hou Y; Beijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, People's Republic of China.
  • Zhou Y; School of Life Science and Technology, University of Electronic Science and Technology of China , Chengdu 610054, People's Republic of China.
  • Wang H; Beijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, People's Republic of China.
  • Wang R; College of Chemistry and Environment Protection Engineering, Southwest University for Nationalities , Chengdu 610041, People's Republic of China.
  • Yuan J; Beijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, People's Republic of China.
  • Hu Y; Beijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, People's Republic of China.
  • Sheng K; Peking-Tsinghua Center for Life Sciences, Peking University , Beijing 100871, People's Republic of China.
  • Feng J; Beijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, People's Republic of China.
  • Yang S; School of Life Science and Technology, University of Electronic Science and Technology of China , Chengdu 610054, People's Republic of China.
  • Lu H; College of Chemistry and Environment Protection Engineering, Southwest University for Nationalities , Chengdu 610041, People's Republic of China.
J Am Chem Soc ; 140(3): 1170-1178, 2018 01 24.
Article em En | MEDLINE | ID: mdl-29262256
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferons / Compostos Macrocíclicos / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: J Am Chem Soc Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferons / Compostos Macrocíclicos / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: J Am Chem Soc Ano de publicação: 2018 Tipo de documento: Article