The effects of growth hormone therapy on the somatic development of a group of Polish children with Silver-Russell syndrome.
Neuro Endocrinol Lett
; 38(6): 415-421, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29298282
ABSTRACT
OBJECTIVE:
Silver-Russell Syndrome is both clinically and genetically a heterogeneous syndrome. Among the most important dysmorphic features of this condition are a triangular shaped face with a small mandible, a prominent frontal eminence, a thin vermilion border with downward-pointing lip corners, clino- and brachydactyly of the 5th fingers as well as body asymmetry. The most well-known genetic mutations in this syndrome are the 11p15 epimutation (20-60% patients) and the maternal uniparental chromosome 7 disomy present in 7% to 15% of patients. Children with SRS have severely impaired physical growth - intrauterine and after birth. This, together with the aforementioned dysmorphic features, forms the main diagnostic criteria. MATERIAL ANDMETHODS:
The study group consisted of 12 children treated with growth hormone, aged 2 to 17 (8.9±4.0 years), therein, all of whom met the phenotype diagnostic criteria by Wollmann and Price. The effects of growth hormone therapy on somatic development of these children are also presented.RESULTS:
Height and weight improved as a result of growth hormone treatment, but the effects were significantly worse than in children with IUGR. Children from the study group presented also a smaller an improvement in growth velocity than children from the control group, but the difference was statistically insignificant.CONCLUSIONS:
Growth hormone therapy accelerates the growth of children with SRS but to a smaller extent than the growth of children born with intrauterine growth retardation without dysmorphic features.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estatura
/
Desenvolvimento Infantil
/
Hormônio do Crescimento Humano
/
Síndrome de Silver-Russell
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Neuro Endocrinol Lett
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Polônia