Donor CD163 and nestin-positive cells predict graft function in living donor liver transplant.
Clin Transplant
; 32(3): e13197, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29323760
ABSTRACT
AIMS:
To evaluate the effect of donor liver resident mesenchymal cells, M2 macrophages on liver graft outcome after living donor liver transplantation. MATERIALS ANDMETHODS:
Seventy donor biopsies were included in the study. Outcomes at day 3, 7, 30, and 180 postliver transplantation were assessed. Mesenchymal stem cells and M2 macrophages in donor liver biopsies were evaluated.RESULTS:
Mean age of recipients was 40.9 ± 13.6 years. Sex mismatched transplants were 44 (MâF = 9; FâM = 35). On area under receiver operative curve analysis, donor biopsy (DB) nestin ≥3 and CD 163 ≥ 32/200x at day 3; CD163 ≥ 32 at day 7; CD 163 > 32, pRBC of <6.5 units at day 30, and DB nestin ≥3, CD 163 ≥ 32 and pRBC<6.5 units at day 180 predicted adequate graft functions. On multivariate analysis, higher DB nestin (P = .009) and lower cryoprecipitate (P = .009) usage at day 3, higher DB CD163 (P = .006) at day 7, higher DB CD163 (P = .018) and reduced transfusion of packed cell (pRBC) (P = .014) at day 30 and higher DB nestin (P = .011), higher CD163 (P = .009), and reduced pRBC (P = .045) at day 180 were the predictors of better outcome.CONCLUSIONS:
Donor liver biopsy nestin+ and CD163+ can predict early graft outcome in living donor liver transplantation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos de Diferenciação Mielomonocítica
/
Antígenos CD
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Transplante de Fígado
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Receptores de Superfície Celular
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Doadores Vivos
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Nestina
/
Sobrevivência de Enxerto
/
Hepatopatias
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin Transplant
Assunto da revista:
TRANSPLANTE
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Índia