Inhibition of HSP90&#945; protects cultured neurons from oxygen-glucose deprivation induced necroptosis by decreasing RIP3 expression.

Wang, Zhen; Guo, Li-Min; Wang, Yong; Zhou, Hong-Kang; Wang, Shu-Chao; Chen, Dan; Huang, Ju-Fang; Xiong, Kun

Inhibition of HSP90α protects cultured neurons from oxygen-glucose deprivation induced necroptosis by decreasing RIP3 expression.

Wang, Zhen; Guo, Li-Min; Wang, Yong; Zhou, Hong-Kang; Wang, Shu-Chao; Chen, Dan; Huang, Ju-Fang; Xiong, Kun.

Afiliação

Wang Z; Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China.
Guo LM; Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China.
Wang Y; Department of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China.
Zhou HK; Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China.
Wang SC; Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China.
Chen D; Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China.
Huang JF; Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China.
Xiong K; Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China.

J Cell Physiol ; 233(6): 4864-4884, 2018 06.

Article em En | MEDLINE | ID: mdl-29334122

Assuntos

Apoptose/efeitos dos fármacos; Benzoquinonas/farmacologia; Córtex Cerebral/efeitos dos fármacos; Glucose/deficiência; Proteínas de Choque Térmico HSP90/antagonistas & inibidores; Lactamas Macrocíclicas/farmacologia; Neurônios/efeitos dos fármacos; Fármacos Neuroprotetores/farmacologia; Proteína Serina-Treonina Quinases de Interação com Receptores/metabolismo; Animais; Hipóxia Celular; Córtex Cerebral/embriologia; Córtex Cerebral/enzimologia; Córtex Cerebral/patologia; Regulação para Baixo; Feminino; Idade Gestacional; Proteínas de Choque Térmico HSP90/genética; Proteínas de Choque Térmico HSP90/metabolismo; Necrose; Neurônios/enzimologia; Neurônios/patologia; Células PC12; Gravidez; Cultura Primária de Células; Ligação Proteica; Proteínas Quinases/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Interferência de RNA; RNA Interferente Pequeno/genética; RNA Interferente Pequeno/metabolismo; Ratos; Ratos Sprague-Dawley; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

cultured neurons; heat shock protein 90 α; necroptosis; oxygen and glucose deprivation; receptor interacting protein 3

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Cerebral / Benzoquinonas / Apoptose / Fármacos Neuroprotetores / Proteínas de Choque Térmico HSP90 / Lactamas Macrocíclicas / Proteína Serina-Treonina Quinases de Interação com Receptores / Glucose / Neurônios Limite: Animals / Pregnancy Idioma: En Revista: J Cell Physiol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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